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• W2979223348 abstract "Aim: The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to clear cell renal cell carcinoma (ccRCC). Materials & methods: A total of 284 ccRCC patients and 439 healthy volunteers were enrolled. Totally three tag single nucleotide polymorphisms in AXIN1 gene were genotyped using PCR & restriction fragment length polymorphism. Results: Significantly increased ccRCC risk was observed to be associated with the CT/CC genotypes of rs1805105 and AA genotype of rs12921862. Patients carrying the rs1805105 CT genotype had a 1.92-fold increased risk to developing clinical stage III and IV cancer. Conclusion: Our results suggested the rs1805105 CT/CC genotypes and rs12921862 AA genotype may relate to ccRCC development." @default.
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• W2979223348 date "2017-11-01" @default.
• W2979223348 modified "2023-09-26" @default.
• W2979223348 title "Genetic association of polymorphisms in <i>AXIN1</i> gene with clear cell renal cell carcinoma in a Chinese population" @default.
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• W2979223348 doi "https://doi.org/10.2217/bmm-2016-0377" @default.
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