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• W2979227573 startingPage "1143" @default.
• W2979227573 abstract "Abstract Salmonella enterica serovar Typhimurium ( S . Tm) is a major intracellular pathogen that infects humans and animals, and its survival and growth in macrophages is essential for its pathogenicity. More than 50 putative regulatory proteins are encoded by the S . Tm genome, but the functions of these regulatory proteins in mediating S . Tm pathogenicity are largely unknown. In this study, we investigated the biological function of the STM0030 gene, which encodes a putative LysR‐type transcriptional regulator. We found that STM0030 is upregulated 2.8–5.7‐fold during S . Tm growth in macrophages. Further, mutating this gene decreased bacterial growth in macrophages and attenuated virulence in mice. RNA‐sequencing to investigate the regulatory function of STM0030 in S . Tm revealed that 447 genes were differentially expressed between the mutant and the wild‐type strains; 429 of these genes were downregulated, suggesting that STM0030 mainly acts as a transcriptional activator. Moreover, the expression of gluconate, maltose, and hexose‐p transport genes, as well as allantoin utilization genes were downregulated in the STM0030 mutant; this might be associated with the observed decrease in intracellular replication and pathogenicity of the mutant. Our findings suggest that STM0030 is a new pathogenicity‐associated regulatory protein that broadens our understanding of the virulence regulatory network of S . Tm." @default.
• W2979227573 created "2019-10-10" @default.
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• W2979227573 date "2019-10-02" @default.
• W2979227573 modified "2023-10-01" @default.
• W2979227573 title "The LysR-type transcriptional regulator STM0030 contributes to <i>Salmonella</i> Typhimurium growth in macrophages and virulence in mice" @default.
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• W2979227573 doi "https://doi.org/10.1002/jobm.201900315" @default.
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