Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979237768> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2979237768 endingPage "2775" @default.
- W2979237768 startingPage "2765" @default.
- W2979237768 abstract "To gain insight into the role of Myc family oncoproteins and their associated protein Max in vertebrate growth and development, we sought to identify homologs in the zebra fish (Brachydanio rerio). A combination of a polymerase chain reaction-based cloning strategy and low-stringency hybridization screening allowed for the isolation of zebra fish c-, N-, and L-myc and max genes; subsequent structural characterization showed a high degree of conservation in regions that encode motifs of known functional significance. On the functional level, zebra fish Max, like its mammalian counterpart, served to suppress the transformation activity of mouse c-Myc in rat embryo fibroblasts. In addition, the zebra fish c-myc gene proved capable of cooperating with an activated H-ras to effect the malignant transformation of mammalian cells, albeit with diminished potency compared with mouse c-myc. With respect to their roles in normal developing tissues, the differential temporal and spatial patterns of steady-state mRNA expression observed for each zebra fish myc family member suggest unique functions for L-myc in early embryogenesis, for N-myc in establishment and growth of early organ systems, and for c-myc in increasingly differentiated tissues. Furthermore, significant alterations in the steady-state expression of zebra fish myc family genes concomitant with relatively constant max expression support the emerging model of regulation of Myc function in cellular growth and differentiation." @default.
- W2979237768 created "2019-10-10" @default.
- W2979237768 creator A5025976657 @default.
- W2979237768 creator A5087465149 @default.
- W2979237768 creator A5088489641 @default.
- W2979237768 date "1993-05-01" @default.
- W2979237768 modified "2023-10-14" @default.
- W2979237768 title "Zebra Fish <i>myc</i> Family and <i>max</i> Genes: Differential Expression and Oncogenic Activity throughout Vertebrate Evolution" @default.
- W2979237768 cites W1558516755 @default.
- W2979237768 cites W1599313043 @default.
- W2979237768 cites W1715467596 @default.
- W2979237768 cites W1817497598 @default.
- W2979237768 cites W1968710429 @default.
- W2979237768 cites W1980110416 @default.
- W2979237768 cites W1980642761 @default.
- W2979237768 cites W1989009382 @default.
- W2979237768 cites W1990205754 @default.
- W2979237768 cites W1991826157 @default.
- W2979237768 cites W1997261857 @default.
- W2979237768 cites W2000002736 @default.
- W2979237768 cites W2000508981 @default.
- W2979237768 cites W2000969961 @default.
- W2979237768 cites W2009310436 @default.
- W2979237768 cites W2018592141 @default.
- W2979237768 cites W2025438239 @default.
- W2979237768 cites W2027290159 @default.
- W2979237768 cites W2029953159 @default.
- W2979237768 cites W2049114614 @default.
- W2979237768 cites W2049214213 @default.
- W2979237768 cites W2059627145 @default.
- W2979237768 cites W2063916615 @default.
- W2979237768 cites W2065301449 @default.
- W2979237768 cites W2068259648 @default.
- W2979237768 cites W2072368091 @default.
- W2979237768 cites W2072392608 @default.
- W2979237768 cites W2077926756 @default.
- W2979237768 cites W2078878501 @default.
- W2979237768 cites W2088665501 @default.
- W2979237768 cites W2089327546 @default.
- W2979237768 cites W2091365260 @default.
- W2979237768 cites W2096462919 @default.
- W2979237768 cites W2125096583 @default.
- W2979237768 cites W2127321901 @default.
- W2979237768 cites W2139996627 @default.
- W2979237768 cites W2142209458 @default.
- W2979237768 cites W2163307259 @default.
- W2979237768 cites W2164107824 @default.
- W2979237768 cites W2312541190 @default.
- W2979237768 cites W4236512674 @default.
- W2979237768 cites W4243043576 @default.
- W2979237768 cites W4709666 @default.
- W2979237768 cites W91742334 @default.
- W2979237768 doi "https://doi.org/10.1128/mcb.13.5.2765-2775.1993" @default.
- W2979237768 hasPublicationYear "1993" @default.
- W2979237768 type Work @default.
- W2979237768 sameAs 2979237768 @default.
- W2979237768 citedByCount "1" @default.
- W2979237768 crossrefType "journal-article" @default.
- W2979237768 hasAuthorship W2979237768A5025976657 @default.
- W2979237768 hasAuthorship W2979237768A5087465149 @default.
- W2979237768 hasAuthorship W2979237768A5088489641 @default.
- W2979237768 hasConcept C104317684 @default.
- W2979237768 hasConcept C150194340 @default.
- W2979237768 hasConcept C2776878037 @default.
- W2979237768 hasConcept C2778961482 @default.
- W2979237768 hasConcept C2909208804 @default.
- W2979237768 hasConcept C505870484 @default.
- W2979237768 hasConcept C54355233 @default.
- W2979237768 hasConcept C78458016 @default.
- W2979237768 hasConcept C86803240 @default.
- W2979237768 hasConceptScore W2979237768C104317684 @default.
- W2979237768 hasConceptScore W2979237768C150194340 @default.
- W2979237768 hasConceptScore W2979237768C2776878037 @default.
- W2979237768 hasConceptScore W2979237768C2778961482 @default.
- W2979237768 hasConceptScore W2979237768C2909208804 @default.
- W2979237768 hasConceptScore W2979237768C505870484 @default.
- W2979237768 hasConceptScore W2979237768C54355233 @default.
- W2979237768 hasConceptScore W2979237768C78458016 @default.
- W2979237768 hasConceptScore W2979237768C86803240 @default.
- W2979237768 hasIssue "5" @default.
- W2979237768 hasLocation W29792377681 @default.
- W2979237768 hasOpenAccess W2979237768 @default.
- W2979237768 hasPrimaryLocation W29792377681 @default.
- W2979237768 hasRelatedWork W14788663 @default.
- W2979237768 hasRelatedWork W1531859311 @default.
- W2979237768 hasRelatedWork W2009966535 @default.
- W2979237768 hasRelatedWork W2068289479 @default.
- W2979237768 hasRelatedWork W2095111365 @default.
- W2979237768 hasRelatedWork W2099737709 @default.
- W2979237768 hasRelatedWork W2126925403 @default.
- W2979237768 hasRelatedWork W2781561487 @default.
- W2979237768 hasRelatedWork W2973095164 @default.
- W2979237768 hasRelatedWork W2990042271 @default.
- W2979237768 hasVolume "13" @default.
- W2979237768 isParatext "false" @default.
- W2979237768 isRetracted "false" @default.
- W2979237768 magId "2979237768" @default.
- W2979237768 workType "article" @default.