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- W2979254304 abstract "Purpose: Endoscopic variceal ligation(EVL) is an effective option in treatment of esophageal varices bleeding or elective ablation.Ulceration after EVL is well recognised but the effect of acid suppression on ulcer healing is not determined definitely. In this study we tried to evaluate efficacy of omeprazol as most available ppi on number and size of esophageal ulcers after EVL in patients, elective candidates to this procedure. Methods: We performed a double -blinded randomised, placebo controled trial of omeprazol after elective EVL. Fifty concecutive cirrhotic and non cirrhotic patients who were cadidated for EVL randomly entered in case(25) and control(25) groups. After endoscopy and EVL, case subjects recieved omeprazol 20 mg bid for 2 weeks and control subjects received placebo for the same period. Follow up endoscopy was performed 12–16 days after EVL. Results: Forty two patients (20 caces and 22 controls) completed the study. Number and size of ulcers were evaluated at follow up endoscopy. Number of ulcers was significantly higher in control group (3.15 vs.2.59, p= 0.03). The ulcers in omeprazole group were on average half as large as in the placebo group (37.08 mm2 vs.73.74 mm2, p < 0.0001). Conclusions: Patients treated by omeprazol after elective EVL had significantly reduction in number and size of post banding ulcers. It seems that omeprazol reduces ulcers number and size after EVL." @default.
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- W2979254304 date "2006-09-01" @default.
- W2979254304 modified "2023-09-27" @default.
- W2979254304 title "Effect of Omeprazole on the Size and Number of Postbanding Ulcers after Esophageal Variceal Band Ligation" @default.
- W2979254304 doi "https://doi.org/10.14309/00000434-200609001-01333" @default.
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