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- W2979257208 abstract "Purpose: Paradoxical vocal fold motion (PVFM) is an inappropriate adduction of the true vocal folds, which causes airway obstruction and inspiratory stridor. PVFM may lead to wheezing and is often mistaken for asthma, and patients are treated with glucocorticoids and beta-agonists inappropriately. There is a body of evidence stating that irritation of the vocal folds may cause or exacerbate PVFM. One-third of PVFM patients have been shown to report GERD symptoms, but studies to evaluate PVFM patients with pH monitoring have all been small (<10 subjects). We studied patients with PVFM to determine the prevalence of GERD in this population as diagnosed by esophagogastroduodenoscopy (EGD) or 48-hour esophageal acid monitoring. Methods: Patients diagnosed with PVFM by flattened inspiratory loop on pulmonary function testing underwent EGD with BRAVO capsule placement at 6 cm proximal to SCJ. All patients abstained from acid suppression agents (PPI's, H2RA's) for 7 days prior to the EGD. 48 hours of pH monitoring was performed with the BRAVO capsule. Patients were considered to have a diagnosis of GERD if they had any evidence of erosive esophagitis on EGD or if they had a positive Johnston-Demeester (JD) score (>22) during the second 24-hour period of pH monitoring by BRAVO capsule. Results: 32 patients (20 females, mean age 42 + 16 yrs) with PVFM completed the study. 31% (10/32) of subjects had a positive JD score, 50% of which had significant combined upright and supine reflux. On EGD, 18.8% (6/32) had evidence of esophagitis. Two subjects with esophagitis had a normal JD score. In this study the prevalence of GERD in PVFM was 37.5% (12/32, 95% CI 21.1–56.3%). Of GERD positive subjects, 50% (6/12) had evidence of esophagitis and 50% had atypical or no symptoms of GERD. GERD pos and GERD neg groups were similar in mean age (43 + 16 yrs vs. 41 + 16 yrs, P= 0.708) and sex (female, 50% of GERD pos vs. 70% of GERD neg, P= 0.452). Conclusion: GERD prevalence in this study was 37.5%. This suggests a high prevalence of GERD in the PVFM population. Because of this, PVFM patients should be studied for GERD, especially since many are asymptomatic. This may also suggest that GERD plays a role in the pathogenesis of PVFM." @default.
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- W2979257208 date "2008-09-01" @default.
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- W2979257208 title "The Prevalence of Gastroesophageal Reflux in Patients with Paradoxical Vocal Fold Motion" @default.
- W2979257208 doi "https://doi.org/10.14309/00000434-200809001-00064" @default.
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