FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979280573> ?p ?o ?g. }

• W2979280573 endingPage "S62" @default.
• W2979280573 startingPage "S61" @default.
• W2979280573 abstract "Purpose: We developed a novel monoclonal antibody, mAb Das-1, that recognizes Barrett's epithelium (BE) with 100% sensitivity and specificity. mAb Das-1 reacts with normal colon epithelium but does not react with normal esophagus, EGJ epithelium, gastric or small intestinal epithelium. COX-2 is expressed in the presence of inflammation and in BE. However, expression of these markers at the EGJ in patients with symptomatic GERD with normal histology is unknown. Methods: Patients with symptomatic GERD (N = 86) were enrolled prospectively and 3 to 4 quadrantic biopsy specimens were taken from EGJ during endoscopy. Using immunoperoxidase assays, mAb Das-1 and anti-COX-2 antibody reactivity was assessed in serial sections of paraffin blocks of EGJ biopsy tissue. Thirty-six patients had normal histology, 50 had esophagitis and none had CM. Fourteen samples with adenocarcinoma of the esophagus were included. Normal biopsy specimens from the esophagus (N = 6), small bowel (N = 10) and colon (N = 15) were included as controls. Results: mAb Das-1 reactivity at EGJ was observed in 4 of 36 (11%) patients with normal histology and 7 of 50 (14%) with esophagitis. COX-2 reactivity was found in 9 of 36 (25%) with normal histology and 20 of 50 (40%) with esophagitis. All 14 patients with adenocarcinoma reacted with both mAb Das-1 and anti-COX-2. Three of 4 (75%) patients with mAb Das-1 positivity with normal histology were also reactive to COX-2. COX-2 expression was absent in all control specimens. However, mAb Das-1 reactivity was present in colon epithelium but absent from esophagus and small bowel epithelium. Conclusions: A metaplastic process expressing colonic phenotype of epithelium is found in 13% of EGJ biopsy tissue of symptomatic GERD patients in the absence of histologic CM. COX-2 expression was found in 34% of EGJ tissue of symptomatic GERD patients without CM. These data indicate that subclinical molecular changes at the EGJ, including metaplastic process, occur in some patients with GERD. This strongly supports the existence of a “pre-Barrett's” metaplastic stage. Such molecular diagnosis of early metaplastic process may allow initiation of early interventional treatment against further progression with PPI or other therapy." @default.
• W2979280573 created "2019-10-10" @default.
• W2979280573 creator A5004422728 @default.
• W2979280573 creator A5007906799 @default.
• W2979280573 creator A5057087677 @default.
• W2979280573 creator A5071991131 @default.
• W2979280573 date "2006-09-01" @default.
• W2979280573 modified "2023-09-26" @default.
• W2979280573 title "Molecular Changes at the Esophagogastric Junction (EGJ) in Patients with Symptomatic Gastroesophageal Reflux Disease (GERD) in the Absence of Histological Columnar Metaplasia (CM)" @default.
• W2979280573 doi "https://doi.org/10.14309/00000434-200609001-00058" @default.
• W2979280573 hasPublicationYear "2006" @default.
• W2979280573 type Work @default.
• W2979280573 sameAs 2979280573 @default.
• W2979280573 citedByCount "0" @default.
• W2979280573 crossrefType "journal-article" @default.
• W2979280573 hasAuthorship W2979280573A5004422728 @default.
• W2979280573 hasAuthorship W2979280573A5007906799 @default.
• W2979280573 hasAuthorship W2979280573A5057087677 @default.
• W2979280573 hasAuthorship W2979280573A5071991131 @default.
• W2979280573 hasConcept C121608353 @default.
• W2979280573 hasConcept C126322002 @default.
• W2979280573 hasConcept C142724271 @default.
• W2979280573 hasConcept C2775934546 @default.
• W2979280573 hasConcept C2776497702 @default.
• W2979280573 hasConcept C2777014526 @default.
• W2979280573 hasConcept C2777819096 @default.
• W2979280573 hasConcept C2779134260 @default.
• W2979280573 hasConcept C2779357193 @default.
• W2979280573 hasConcept C2779422922 @default.
• W2979280573 hasConcept C2781182431 @default.
• W2979280573 hasConcept C43270747 @default.
• W2979280573 hasConcept C57742111 @default.
• W2979280573 hasConcept C71924100 @default.
• W2979280573 hasConcept C90924648 @default.
• W2979280573 hasConceptScore W2979280573C121608353 @default.
• W2979280573 hasConceptScore W2979280573C126322002 @default.
• W2979280573 hasConceptScore W2979280573C142724271 @default.
• W2979280573 hasConceptScore W2979280573C2775934546 @default.
• W2979280573 hasConceptScore W2979280573C2776497702 @default.
• W2979280573 hasConceptScore W2979280573C2777014526 @default.
• W2979280573 hasConceptScore W2979280573C2777819096 @default.
• W2979280573 hasConceptScore W2979280573C2779134260 @default.
• W2979280573 hasConceptScore W2979280573C2779357193 @default.
• W2979280573 hasConceptScore W2979280573C2779422922 @default.
• W2979280573 hasConceptScore W2979280573C2781182431 @default.
• W2979280573 hasConceptScore W2979280573C43270747 @default.
• W2979280573 hasConceptScore W2979280573C57742111 @default.
• W2979280573 hasConceptScore W2979280573C71924100 @default.
• W2979280573 hasConceptScore W2979280573C90924648 @default.
• W2979280573 hasLocation W29792805731 @default.
• W2979280573 hasOpenAccess W2979280573 @default.
• W2979280573 hasPrimaryLocation W29792805731 @default.
• W2979280573 hasRelatedWork W1545832077 @default.
• W2979280573 hasRelatedWork W16550586 @default.
• W2979280573 hasRelatedWork W1976757422 @default.
• W2979280573 hasRelatedWork W2031134104 @default.
• W2979280573 hasRelatedWork W2073176061 @default.
• W2979280573 hasRelatedWork W2153496602 @default.
• W2979280573 hasRelatedWork W2243644483 @default.
• W2979280573 hasRelatedWork W2323997965 @default.
• W2979280573 hasRelatedWork W2499280654 @default.
• W2979280573 hasRelatedWork W3020734536 @default.
• W2979280573 hasVolume "101" @default.
• W2979280573 isParatext "false" @default.
• W2979280573 isRetracted "false" @default.
• W2979280573 magId "2979280573" @default.
• W2979280573 workType "article" @default.