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- W2979308003 endingPage "3694" @default.
- W2979308003 startingPage "3694" @default.
- W2979308003 abstract "Nucleic acids and proteins are two major classes of biopolymers in living systems. Whereas nucleic acids are characterized by robust molecular recognition properties, essential for the reliable storage and transmission of the genetic information, the variability of structures displayed by proteins and their adaptability to the environment make them ideal functional materials. One of the major goals of DNA nanotechnology—and indeed its initial motivation—is to bridge these two worlds in a rational fashion. Combining the predictable base-pairing rule of DNA with chemical conjugation strategies and modern protein engineering methods has enabled the realization of complex DNA-protein architectures with programmable structural features and intriguing functionalities. In this review, we will focus on a special class of biohybrid structures, characterized by one or many enzyme molecules linked to a DNA scaffold with nanometer-scale precision. After an initial survey of the most important methods for coupling DNA oligomers to proteins, we will report the strategies adopted until now for organizing these conjugates in a predictable spatial arrangement. The major focus of this review will be on the consequences of such manipulations on the binding and kinetic properties of single enzymes and enzyme complexes: an interesting aspect of artificial DNA-enzyme hybrids, often reported in the literature, however, not yet entirely understood and whose full comprehension may open the way to new opportunities in protein science." @default.
- W2979308003 created "2019-10-18" @default.
- W2979308003 creator A5023371876 @default.
- W2979308003 creator A5034731375 @default.
- W2979308003 creator A5075803366 @default.
- W2979308003 date "2019-10-14" @default.
- W2979308003 modified "2023-10-15" @default.
- W2979308003 title "Manipulating Enzymes Properties with DNA Nanostructures" @default.
- W2979308003 cites W1617520624 @default.
- W2979308003 cites W1656731888 @default.
- W2979308003 cites W1964599873 @default.
- W2979308003 cites W1965560011 @default.
- W2979308003 cites W1974119662 @default.
- W2979308003 cites W1983647569 @default.
- W2979308003 cites W1987448823 @default.
- W2979308003 cites W1989176881 @default.
- W2979308003 cites W1989548144 @default.
- W2979308003 cites W1996816533 @default.
- W2979308003 cites W2005615084 @default.
- W2979308003 cites W2007272508 @default.
- W2979308003 cites W2008686601 @default.
- W2979308003 cites W2012030321 @default.
- W2979308003 cites W2014686336 @default.
- W2979308003 cites W2016036293 @default.
- W2979308003 cites W2016907728 @default.
- W2979308003 cites W2021755139 @default.
- W2979308003 cites W2028293394 @default.
- W2979308003 cites W2030673893 @default.
- W2979308003 cites W2032542581 @default.
- W2979308003 cites W2034096144 @default.
- W2979308003 cites W2037908382 @default.
- W2979308003 cites W2038125628 @default.
- W2979308003 cites W2039730742 @default.
- W2979308003 cites W2043951705 @default.
- W2979308003 cites W2050630660 @default.
- W2979308003 cites W2052859437 @default.
- W2979308003 cites W2057788156 @default.
- W2979308003 cites W2063030872 @default.
- W2979308003 cites W2063912934 @default.
- W2979308003 cites W2068161092 @default.
- W2979308003 cites W2070976932 @default.
- W2979308003 cites W2082015621 @default.
- W2979308003 cites W2082254190 @default.
- W2979308003 cites W2088885969 @default.
- W2979308003 cites W2094524922 @default.
- W2979308003 cites W2095886160 @default.
- W2979308003 cites W2095914211 @default.
- W2979308003 cites W2110268942 @default.
- W2979308003 cites W2110776558 @default.
- W2979308003 cites W2117876468 @default.
- W2979308003 cites W2119635496 @default.
- W2979308003 cites W2119888102 @default.
- W2979308003 cites W2120380574 @default.
- W2979308003 cites W2124230566 @default.
- W2979308003 cites W2126961173 @default.
- W2979308003 cites W2134178604 @default.
- W2979308003 cites W2138234690 @default.
- W2979308003 cites W2143596706 @default.
- W2979308003 cites W2144844133 @default.
- W2979308003 cites W2145288435 @default.
- W2979308003 cites W2156578843 @default.
- W2979308003 cites W2164697359 @default.
- W2979308003 cites W2182062935 @default.
- W2979308003 cites W2192072986 @default.
- W2979308003 cites W2279766373 @default.
- W2979308003 cites W2285767004 @default.
- W2979308003 cites W2301507491 @default.
- W2979308003 cites W2315687649 @default.
- W2979308003 cites W2316954248 @default.
- W2979308003 cites W2318287273 @default.
- W2979308003 cites W2322844285 @default.
- W2979308003 cites W2323436860 @default.
- W2979308003 cites W2323641583 @default.
- W2979308003 cites W2331719657 @default.
- W2979308003 cites W2335219798 @default.
- W2979308003 cites W2346386833 @default.
- W2979308003 cites W2420017280 @default.
- W2979308003 cites W2480259124 @default.
- W2979308003 cites W2566722304 @default.
- W2979308003 cites W2588424256 @default.
- W2979308003 cites W2612422703 @default.
- W2979308003 cites W2764088697 @default.
- W2979308003 cites W2792466840 @default.
- W2979308003 cites W2891534929 @default.
- W2979308003 cites W2892934299 @default.
- W2979308003 cites W2895057567 @default.
- W2979308003 cites W2908890319 @default.
- W2979308003 cites W2911766284 @default.
- W2979308003 cites W2913121738 @default.
- W2979308003 cites W2920284863 @default.
- W2979308003 cites W2947890389 @default.
- W2979308003 cites W2951657988 @default.
- W2979308003 cites W318777421 @default.
- W2979308003 doi "https://doi.org/10.3390/molecules24203694" @default.
- W2979308003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6832416" @default.
- W2979308003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31615123" @default.
- W2979308003 hasPublicationYear "2019" @default.
- W2979308003 type Work @default.