Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979317446> ?p ?o ?g. }
- W2979317446 endingPage "13" @default.
- W2979317446 startingPage "1" @default.
- W2979317446 abstract "The emergence of targeted therapy for patients with hematological diseases has permanently altered the therapeutic landscape. Immunochemotherapy regimes are now more and more being replaced by targeted therapies due to superior efficacy and better safety profiles. However, evolution and selection of subclones with continuous treatment leads to disease relapse and resistance toward these novel drugs. Venetoclax, the highly selective BCL-2 inhibitor (ABT-199), has an acceptable safety profile. To date, it has been approved for the treatment of first-line and relapsed/refractory chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, extension of indications can be expected in monotherapy and in combination regimens with promising outcomes in other hematological diseases. In this article, we describe the mechanism of action that stands behind the efficacy of venetoclax and provide a summary of available results from clinical trials." @default.
- W2979317446 created "2019-10-18" @default.
- W2979317446 creator A5022694808 @default.
- W2979317446 creator A5082229739 @default.
- W2979317446 creator A5088339814 @default.
- W2979317446 date "2019-10-09" @default.
- W2979317446 modified "2023-10-10" @default.
- W2979317446 title "Venetoclax: evidence to date and clinical potential" @default.
- W2979317446 cites W146673805 @default.
- W2979317446 cites W1933867057 @default.
- W2979317446 cites W1973421470 @default.
- W2979317446 cites W1998574350 @default.
- W2979317446 cites W2007648282 @default.
- W2979317446 cites W2029862675 @default.
- W2979317446 cites W2045399297 @default.
- W2979317446 cites W2062358377 @default.
- W2979317446 cites W2064223130 @default.
- W2979317446 cites W2064323879 @default.
- W2979317446 cites W2066640259 @default.
- W2979317446 cites W2073966063 @default.
- W2979317446 cites W2088634057 @default.
- W2979317446 cites W2088883749 @default.
- W2979317446 cites W2102461774 @default.
- W2979317446 cites W2108206643 @default.
- W2979317446 cites W2115577067 @default.
- W2979317446 cites W2119691395 @default.
- W2979317446 cites W2119960600 @default.
- W2979317446 cites W2132433919 @default.
- W2979317446 cites W2135551958 @default.
- W2979317446 cites W2147318282 @default.
- W2979317446 cites W2147852317 @default.
- W2979317446 cites W2153923291 @default.
- W2979317446 cites W2168632005 @default.
- W2979317446 cites W2172242534 @default.
- W2979317446 cites W2192121806 @default.
- W2979317446 cites W2215425676 @default.
- W2979317446 cites W2215798291 @default.
- W2979317446 cites W2221325899 @default.
- W2979317446 cites W2278193989 @default.
- W2979317446 cites W2310716991 @default.
- W2979317446 cites W2318933236 @default.
- W2979317446 cites W2329613393 @default.
- W2979317446 cites W2342878392 @default.
- W2979317446 cites W2369297677 @default.
- W2979317446 cites W2409945629 @default.
- W2979317446 cites W2507725926 @default.
- W2979317446 cites W2516164871 @default.
- W2979317446 cites W2517675534 @default.
- W2979317446 cites W2565073516 @default.
- W2979317446 cites W2572899914 @default.
- W2979317446 cites W2582696216 @default.
- W2979317446 cites W2606955324 @default.
- W2979317446 cites W2792666902 @default.
- W2979317446 cites W2800186514 @default.
- W2979317446 cites W2805370126 @default.
- W2979317446 cites W2885823571 @default.
- W2979317446 cites W2898284215 @default.
- W2979317446 cites W2922249564 @default.
- W2979317446 doi "https://doi.org/10.7573/dic.212574" @default.
- W2979317446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6788387" @default.
- W2979317446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31645879" @default.
- W2979317446 hasPublicationYear "2019" @default.
- W2979317446 type Work @default.
- W2979317446 sameAs 2979317446 @default.
- W2979317446 citedByCount "74" @default.
- W2979317446 countsByYear W29793174462020 @default.
- W2979317446 countsByYear W29793174462021 @default.
- W2979317446 countsByYear W29793174462022 @default.
- W2979317446 countsByYear W29793174462023 @default.
- W2979317446 crossrefType "journal-article" @default.
- W2979317446 hasAuthorship W2979317446A5022694808 @default.
- W2979317446 hasAuthorship W2979317446A5082229739 @default.
- W2979317446 hasAuthorship W2979317446A5088339814 @default.
- W2979317446 hasBestOaLocation W29793174461 @default.
- W2979317446 hasConcept C126322002 @default.
- W2979317446 hasConcept C143998085 @default.
- W2979317446 hasConcept C177713679 @default.
- W2979317446 hasConcept C2777938653 @default.
- W2979317446 hasConcept C2778461978 @default.
- W2979317446 hasConcept C2778729363 @default.
- W2979317446 hasConcept C2779134260 @default.
- W2979317446 hasConcept C2779675984 @default.
- W2979317446 hasConcept C535046627 @default.
- W2979317446 hasConcept C71924100 @default.
- W2979317446 hasConcept C98274493 @default.
- W2979317446 hasConceptScore W2979317446C126322002 @default.
- W2979317446 hasConceptScore W2979317446C143998085 @default.
- W2979317446 hasConceptScore W2979317446C177713679 @default.
- W2979317446 hasConceptScore W2979317446C2777938653 @default.
- W2979317446 hasConceptScore W2979317446C2778461978 @default.
- W2979317446 hasConceptScore W2979317446C2778729363 @default.
- W2979317446 hasConceptScore W2979317446C2779134260 @default.
- W2979317446 hasConceptScore W2979317446C2779675984 @default.
- W2979317446 hasConceptScore W2979317446C535046627 @default.
- W2979317446 hasConceptScore W2979317446C71924100 @default.
- W2979317446 hasConceptScore W2979317446C98274493 @default.
- W2979317446 hasLocation W29793174461 @default.
- W2979317446 hasLocation W29793174462 @default.