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• W2979320780 abstract "Suppression of anti-tumor immunity is recognized as a critical step in the development of many types of cancers. Over the past decade, a multitude of immunosuppressive pathways occurring in the tumor microenvironment (TME) have been identified. Amongst them, the hydrolysis of extracellular ATP into adenosine by ecto-nucleotidases has been increasingly documented as new immune checkpoint pathway that can significantly impair anti-tumor immunity of multiple types of cancer. In this review, we summarize past and recent research on the ecto-nucleotidases CD39 and CD73, conducted by our group and others, that recently lead to the development and clinical testing of adenosine targeting agents for cancer immunotherapy." @default.
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• W2979320780 date "2019-04-01" @default.
• W2979320780 modified "2023-10-13" @default.
• W2979320780 title "Targeting the adenosine pathway for cancer immunotherapy" @default.
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• W2979320780 doi "https://doi.org/10.1016/j.smim.2019.101304" @default.
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