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- W29793329 abstract "Considerable experimental evidence has accrued from animal studies that implicate dietary fats as important modulators of ultraviolet (UVR)-carcinogenic expression. These fats are composed of essential fatty acids (EFA) and are grouped into two families of polyunsaturated fatty acids (PUFA), omega (ω)-6 and omega (ω)-3 fatty acids (FA). They are essential in that they are precursors of a group of highly active hormones, eicosanoids, that are necessary for normal growth and maintenance of health. Relatively minor differences in molecular structure of these FA not only cause them to act differently in the body, but also to produce diverse effects in modulation of carcinogenic expression. Dietary ω-6 FA has been shown to exacerbate UVR carcinogenic expression (tumor latent period and tumor multiplicity) in a manner that is directly related to level of FA intake. Dietary ω-3 FA inhibits UVR carcinogenic expression. Pro-inflammatory and immunosuppressive eicosanoids, e.g. prostaglandin E2 (PGE2) levels increase in a linear fashion with the concentration of ω-6 FA intake. These levels are dramatically reduced with ω-3 FA intake. ω-6 FA intake suppresses the immunologic pathways manifested in delayed hypersensitivity (DTH) and the responses involved in tumor transplant rejection. ω-3 FA sustains the DTH response in UVR-irradiated animals. Clinical studies have found that supplementary ω-3 FA significantly raise the UVR-mediated erythema threshold and reduce the level of pro-inflammatory and immunosuppressive PGE2 in UVR-irradiated human skin. Taken in toto, these studies suggest that ω-3 supplementation could be beneficial in reducing the occurrence of non-melanoma skin cancer, particularly in those individuals who are at highest risk." @default.
- W29793329 created "2016-06-24" @default.
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- W29793329 date "2012-01-01" @default.
- W29793329 modified "2023-09-26" @default.
- W29793329 title "Omega-3 fatty acids and non-melanoma skin cancer" @default.
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- W29793329 doi "https://doi.org/10.3920/978-90-8686-729-5_22" @default.
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