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• W2979347011 abstract "Loss of mitochondrial DNA (mtDNA) results in loss of mitochondrial respiratory activity, checkpoint-regulated inhibition of cell cycle progression, defects in growth, and nuclear genome instability. However, after several generations, yeast cells can adapt to the loss of mtDNA. During this adaptation, rho 0 cells, which have no mtDNA, exhibit increased growth rates and nuclear genome stabilization. Here, we report that an immediate response to loss of mtDNA is a decrease in replicative lifespan (RLS). Moreover, we find that adapted rho 0 cells bypass the mtDNA inheritance checkpoint, exhibit increased mitochondrial function, and undergo an increase in RLS as they adapt to the loss of mtDNA. Transcriptome analysis reveals that metabolic reprogramming to compensate for defects in mitochondrial function is an early event during adaptation and that up-regulation of stress response genes occurs later in the adaptation process. We also find that specific subtelomeric genes are silenced during adaptation to loss of mtDNA. Moreover, we find that deletion of SIR3, a subtelomeric gene silencing protein, inhibits silencing of subtelomeric genes associated with adaptation to loss of mtDNA, as well as adaptation-associated increases in mitochondrial function and RLS extension." @default.
• W2979347011 created "2019-10-18" @default.
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• W2979347011 date "2019-11-15" @default.
• W2979347011 modified "2023-10-02" @default.
• W2979347011 title "Reciprocal interactions between mtDNA and lifespan control in budding yeast" @default.
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• W2979347011 doi "https://doi.org/10.1091/mbc.e18-06-0356" @default.
• W2979347011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6857569" @default.
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