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- W2979391377 endingPage "270" @default.
- W2979391377 startingPage "257" @default.
- W2979391377 abstract "Abstract Candida albicans is an opportunistic yeast and the major human fungal pathogen in the USA, as well as in many other regions of the world. Infections with C. albicans can range from superficial mucosal and dermatological infections to life-threatening infections of the bloodstream and vital organs. The azole antifungals remain an important mainstay treatment of candidiasis and therefore the investigation and understanding of the evolution, frequency and mechanisms of azole resistance are vital to improving treatment strategies against this organism. Here the organism C. albicans and the genetic changes and molecular bases underlying the currently known resistance mechanisms to the azole antifungal class are reviewed, including up-regulated expression of efflux pumps, changes in the expression and amino acid composition of the azole target Erg11 and alterations to the organism’s typical sterol biosynthesis pathways. Additionally, we update what is known about activating mutations in the zinc cluster transcription factor (ZCF) genes regulating many of these resistance mechanisms and review azole import as a potential contributor to azole resistance. Lastly, investigations of azole tolerance in C. albicans and its implicated clinical significance are reviewed." @default.
- W2979391377 created "2019-10-18" @default.
- W2979391377 creator A5044179789 @default.
- W2979391377 creator A5052537922 @default.
- W2979391377 creator A5059280370 @default.
- W2979391377 date "2019-10-11" @default.
- W2979391377 modified "2023-10-12" @default.
- W2979391377 title "Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus<i>Candida albicans</i>" @default.
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