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- W2979402488 abstract "Using data from Schink et al. (2018), a large number of herbal extracts were assessed for their capacity to induce pro- and anti-inflammatory effects based on TLR4 expression normalized for cell viability in two immune cell models (i.e., HeLa-TLR4 transfected reporter cell line, and THP-1 monocytes) applying seven concentrations (0.01–3.0%). The analysis revealed that 70–80% of the extracts satisfying the a priori entry criteria also satisfied a priori evaluative criteria for hormetic concentration responses. These findings demonstrate that a large proportion of herbal extracts display hormetic dose responses in immune cells, indicating that hormetic mechanisms mediate pro- and anti-inflammatory processes and may provide a means to guide optimal dosing strategies. The identification of doses eliciting only anti-inflammatory therapeutic activity as well as the use of dose-variable herbal extracts in the treatment of inflammatory diseases will be challenging." @default.
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- W2979402488 date "2019-12-01" @default.
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- W2979402488 title "Re-analysis of herbal extracts data reveals that inflammatory processes are mediated by hormetic mechanisms" @default.
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- W2979402488 doi "https://doi.org/10.1016/j.cbi.2019.108844" @default.
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