Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979404401> ?p ?o ?g. }
- W2979404401 endingPage "9122" @default.
- W2979404401 startingPage "9111" @default.
- W2979404401 abstract "Cardiolipin (CL), an anionic phospholipid constituting 20% of the inner mitochondrial membrane (IMM) of eukaryotes, stabilizes electron transport chain (ETC) complexes and is a signaling agent in the early stages of apoptosis. For apoptosis, CL moves from the inner to the outer leaflet of the IMM via a poorly understood mechanism. Relative to cylindrically shaped lipids like dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylglycerol (DOPG), cone-shaped CL should prefer the concave surfaces of lipid bilayers. Using the fluorophore, 1,1,2,2-tetrakis[4-(2-trimethylammonioethoxy)phenyl]ethene, we have measured CL versus DOPG partitioning to the inner versus the outer leaflet of liposomes in mixed lipid systems with DOPC. DOPG shows no leaflet preference. However, CL has a 4:1 preference for the concave surface of the inner leaflet of liposomes. To further test the inner leaflet preference of CL, we show that cytochrome c binding to the outer convex surface of 20% CL/80% DOPC vesicles is strongly attenuated. Because the outer leaflet of intracristal regions of the IMM has a concave curvature, the preference of CL for concave surfaces may facilitate the transport of CL from the inner to the outer leaflet of the IMM needed for CL remodeling, the optimal functioning of the ETC, and signaling in the early stages of apoptosis." @default.
- W2979404401 created "2019-10-18" @default.
- W2979404401 creator A5020427460 @default.
- W2979404401 creator A5045575167 @default.
- W2979404401 creator A5048184997 @default.
- W2979404401 creator A5066488632 @default.
- W2979404401 creator A5074549149 @default.
- W2979404401 date "2019-10-07" @default.
- W2979404401 modified "2023-09-27" @default.
- W2979404401 title "Cardiolipin Preferentially Partitions to the Inner Leaflet of Mixed Lipid Large Unilamellar Vesicles" @default.
- W2979404401 cites W1491243950 @default.
- W2979404401 cites W1514650462 @default.
- W2979404401 cites W1544177485 @default.
- W2979404401 cites W1551289009 @default.
- W2979404401 cites W1587402437 @default.
- W2979404401 cites W1945465158 @default.
- W2979404401 cites W1974145389 @default.
- W2979404401 cites W1976112620 @default.
- W2979404401 cites W1977748495 @default.
- W2979404401 cites W1981761696 @default.
- W2979404401 cites W1986183780 @default.
- W2979404401 cites W1996796347 @default.
- W2979404401 cites W1999439995 @default.
- W2979404401 cites W1999774021 @default.
- W2979404401 cites W2000634454 @default.
- W2979404401 cites W2002621746 @default.
- W2979404401 cites W2004550803 @default.
- W2979404401 cites W2005441809 @default.
- W2979404401 cites W2012553260 @default.
- W2979404401 cites W2012657176 @default.
- W2979404401 cites W2016660369 @default.
- W2979404401 cites W2022240534 @default.
- W2979404401 cites W2023236182 @default.
- W2979404401 cites W2025144170 @default.
- W2979404401 cites W2027178266 @default.
- W2979404401 cites W2034273954 @default.
- W2979404401 cites W2036513157 @default.
- W2979404401 cites W2037736115 @default.
- W2979404401 cites W2039145478 @default.
- W2979404401 cites W2044143372 @default.
- W2979404401 cites W2046211197 @default.
- W2979404401 cites W2049463380 @default.
- W2979404401 cites W2050547972 @default.
- W2979404401 cites W2052209941 @default.
- W2979404401 cites W2052544119 @default.
- W2979404401 cites W2054739775 @default.
- W2979404401 cites W2055567342 @default.
- W2979404401 cites W2058970378 @default.
- W2979404401 cites W2062897750 @default.
- W2979404401 cites W2067231959 @default.
- W2979404401 cites W2067549126 @default.
- W2979404401 cites W2077637487 @default.
- W2979404401 cites W2078074876 @default.
- W2979404401 cites W2093921916 @default.
- W2979404401 cites W2100872265 @default.
- W2979404401 cites W2112213724 @default.
- W2979404401 cites W2153620216 @default.
- W2979404401 cites W2154206349 @default.
- W2979404401 cites W2158564511 @default.
- W2979404401 cites W2161080023 @default.
- W2979404401 cites W2167315212 @default.
- W2979404401 cites W2170572335 @default.
- W2979404401 cites W2171190437 @default.
- W2979404401 cites W2172086188 @default.
- W2979404401 cites W2177603935 @default.
- W2979404401 cites W2210811658 @default.
- W2979404401 cites W2229781928 @default.
- W2979404401 cites W2231680249 @default.
- W2979404401 cites W2250979710 @default.
- W2979404401 cites W2295199541 @default.
- W2979404401 cites W2299523670 @default.
- W2979404401 cites W2332444796 @default.
- W2979404401 cites W2339294105 @default.
- W2979404401 cites W2507712245 @default.
- W2979404401 cites W2542851683 @default.
- W2979404401 cites W2549155751 @default.
- W2979404401 cites W2561817513 @default.
- W2979404401 cites W2601743360 @default.
- W2979404401 cites W2671326645 @default.
- W2979404401 cites W2748439441 @default.
- W2979404401 cites W2781891748 @default.
- W2979404401 cites W2802682760 @default.
- W2979404401 cites W2804352343 @default.
- W2979404401 cites W2891053995 @default.
- W2979404401 cites W2950108090 @default.
- W2979404401 cites W4242586143 @default.
- W2979404401 doi "https://doi.org/10.1021/acs.jpcb.9b07690" @default.
- W2979404401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31589821" @default.
- W2979404401 hasPublicationYear "2019" @default.
- W2979404401 type Work @default.
- W2979404401 sameAs 2979404401 @default.
- W2979404401 citedByCount "11" @default.
- W2979404401 countsByYear W29794044012020 @default.
- W2979404401 countsByYear W29794044012021 @default.
- W2979404401 countsByYear W29794044012022 @default.
- W2979404401 countsByYear W29794044012023 @default.
- W2979404401 crossrefType "journal-article" @default.
- W2979404401 hasAuthorship W2979404401A5020427460 @default.