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• W2979406738 abstract "Abstract The active vitamin D hormone, 1,25‐dihydroxyvitamin D 3 , exerts many physiological actions in the body, including effects on the nervous system. Studies of steroidogenesis in cells of the nervous system and elsewhere not only indicate that 1,25‐dihydroxyvitamin D 3 affects steroidogenic pathways but also suggest varying responses in different cell types. For example, 1,25‐dihydroxyvitamin D 3 stimulates the expression of aromatase in human glioma but not in human neuroblastoma cells or rat astrocytes. However, in astrocytes, 1,25‐dihydroxyvitamin D 3 suppresses 3β‐hydroxysteroid dehydrogenase and steroid 17‐hydroxylase/lyase. Other studies indicate cross‐talk between vitamin D signalling and signalling of oestrogens, progesterone or glucocorticoids. Reported data indicate synergistic effects of combinations of 1,25‐dihydroxyvitamin D 3 and other steroid hormones on neuroinflammation, neurite outgrowth and neuroprotection. Also, dysregulation of steroid pathways affecting brain cells is found in vitamin D deficiency. Thus, several studies suggest that active vitamin D may affect steroid hormone synthesis and/or signalling in the nervous system, although the potential mechanisms for these responses remain unclear. 1,25‐Dihydroxyvitamin D 3 suppresses proliferation in several cell types and is therefore of interest in cancer treatment. Also, epidemiological studies associate vitamin D levels with cancer risk or outcomes. Reported data on tumours of the nervous system are mainly on glioma, a common type of brain cancer. Expression of the vitamin D receptor in glioma tumours is associated with improved survival. Several studies show that 1,25‐dihydroxyvitamin D 3 and vitamin D analogues (synthetic vitamin D‐like compounds) suppress proliferation and migration in human vitamin D receptor‐expressing glioma cell lines. Studies on mechanisms for actions of 1,25‐dihydroxyvitamin D 3 or its analogues indicate regulation of cell cycle proteins and senescence markers. These compounds also show synergism in combination with other cancer therapies treating glioma. From the data available, vitamin D analogues emerge as interesting candidates for the future improved treatment of human glioma and possibly also other cancers of the nervous system." @default.
• W2979406738 created "2019-10-18" @default.
• W2979406738 creator A5026817106 @default.
• W2979406738 date "2019-10-23" @default.
• W2979406738 modified "2023-09-27" @default.
• W2979406738 title "Effects of vitamin D in the nervous system: Special focus on interaction with steroid hormone signalling and a possible role in the treatment of brain cancer" @default.
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• W2979406738 doi "https://doi.org/10.1111/jne.12799" @default.
• W2979406738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31593305" @default.
• W2979406738 hasPublicationYear "2019" @default.
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