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- W2979417923 abstract "Since their discovery just over 25 years ago, the single variable domain from heavy-chain-only antibodies plays a role in an increasing number of antibody-based applications. Structural and biophysical studies have revealed that the small, ∼15 kDa, single variable domain found in camelids displays versatility in target recognition. Such insight has served as the foundation to develop and engineer VHH domains with enhanced properties capable of targeting a range of therapeutically relevant protein antigens or low-molecular weight haptens. Furthermore, the modular nature of VHH domains allows them to be introduced into constructs that are simply not possible with conventional antibodies. Here, we review the structural and biophysical properties of VHH domains, highlight recent VHH-based therapeutics and diagnostics, and provide insight into VHH engineering that may pave the way to next-generation single domain antibody applications. Impact statement The development of novel antibody formats, beyond conventional antibodies, opens new possibilities in medical therapies, diagnostics, and general life science applications requiring affinity reagents. The camelid VHH domain, from heavy-chain-only antibodies, has emerged as a jack-of-all-trades module for novel affinity reagents. Applications include targeted cancer therapies, novel antimicrobial agents, conformation specific reagents, and tailor-made molecular switch entities. The breadth of unique uses for the VHH will continue to grow, opening new opportunities to treat and understand disease." @default.
- W2979417923 created "2019-10-18" @default.
- W2979417923 creator A5025147600 @default.
- W2979417923 creator A5037676824 @default.
- W2979417923 creator A5071788051 @default.
- W2979417923 date "2019-10-09" @default.
- W2979417923 modified "2023-10-16" @default.
- W2979417923 title "Structure and development of single domain antibodies as modules for therapeutics and diagnostics" @default.
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- W2979417923 doi "https://doi.org/10.1177/1535370219881129" @default.
- W2979417923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6920669" @default.
- W2979417923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31594404" @default.
- W2979417923 hasPublicationYear "2019" @default.
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