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- W2979427590 abstract "Inhibition of host macroautophagy/autophagy is one of the strategies used by several intracellular pathogens, including H. pylori, to escape killing. Here we discuss our recent work that revealed the novel mechanism by which the vacuolating cytotoxin A (VacA) produced by H. pylori inhibits lysosomal and autophagic killing. We discovered that VacA impairs the activity of the lysosomal calcium channel MCOLN1/TRPML1 leading to the formation of enlarged, dysfunctional lysosomes and autophagosomes that serve as an intracellular niche, which allows the bacteria to escape eradication therapy." @default.
- W2979427590 created "2019-10-18" @default.
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- W2979427590 date "2019-10-13" @default.
- W2979427590 modified "2023-10-01" @default.
- W2979427590 title "MCOLN1/TRPML1 inhibition - a novel strategy used by <i>Helicobacter pylori</i> to escape autophagic killing and antibiotic eradication therapy <i>in vivo</i>" @default.
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- W2979427590 doi "https://doi.org/10.1080/15548627.2019.1677322" @default.
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