Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979429061> ?p ?o ?g. }
- W2979429061 startingPage "804294" @default.
- W2979429061 abstract "Abstract Epithelia have distinct cellular architectures, which are established in development, re-established after wounding, and maintained during tissue homeostasis despite cell turnover and mechanical perturbations. In turn, cell shape also controls tissue function as a regulator of cell differentiation, proliferation, and motility. Here we investigate cell shape changes in a model epithelial monolayer. After the onset of confluence, cells continue to divide and change shape over time, eventually leading to a final steady state characterized by arrested motion and more regular cell shapes. Such monolayer remodeling is robust, with qualitatively similar changes in cell shape and dynamics observed in a variety of conditions. However, quantitative differences in monolayer remodeling dynamics reveal underlying order parameters controlling epithelial architecture. For instance, for monolayers formed atop extracellular matrix with varied stiffness, the cell density varies significantly but the relationship between cell shape and motility remain similar. In contrast, pharmacological perturbations can alter the cell shape at which their motility is arrested. Remarkably, across all of these experimental conditions the final cell shape is well correlated to the cell division rate. Furthermore, inhibition of the cell cycle immediately arrests both cell motility and shape change, demonstrating that active stress from cell divisions contributes significantly to monolayer remodeling. Thus, the architecture and mechanics of epithelial tissue can arise from an interplay between cell mechanics and stresses arising from cell division." @default.
- W2979429061 created "2019-10-18" @default.
- W2979429061 creator A5005425034 @default.
- W2979429061 creator A5010013003 @default.
- W2979429061 creator A5030555397 @default.
- W2979429061 creator A5076352231 @default.
- W2979429061 date "2019-10-14" @default.
- W2979429061 modified "2023-09-24" @default.
- W2979429061 title "Cell division Rate Controls Cell Shape Remodeling in Epithelia" @default.
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