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• W2979431029 abstract "Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all domains of life, and its homeostasis must be regulated tightly. Here we report that a Nudix-related transcriptional factor, designated MsNrtR (MSMEG_3198), controls the de novo pathway of NAD+biosynthesis in M. smegmatis, a non-tuberculosis Mycobacterium. The integrated evidence in vitro and in vivo confirms that MsNrtR is an auto-repressor, which negatively controls the de novo NAD+biosynthetic pathway. Binding of MsNrtR cognate DNA is finely mapped, and can be disrupted by an ADP-ribose intermediate. Unexpectedly, we discover that the acetylation of MsNrtR at Lysine 134 participates in the homeostasis of intra-cellular NAD+ level in M. smegmatis. Furthermore, we demonstrate that NrtR acetylation proceeds via the non-enzymatic acetyl-phosphate (AcP) route rather than by the enzymatic Pat/CobB pathway. In addition, the acetylation also occurs on the paralogs of NrtR in the Gram-positive bacterium Streptococcus and the Gram-negative bacterium Vibrio, suggesting that these proteins have a common mechanism of post-translational modification in the context of NAD+ homeostasis. Together, these findings provide a first paradigm for the recruitment of acetylated NrtR to regulate bacterial central NAD+ metabolism." @default.
• W2979431029 created "2019-10-18" @default.
• W2979431029 creator A5022873764 @default.
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• W2979431029 date "2019-10-09" @default.
• W2979431029 modified "2023-10-16" @default.
• W2979431029 title "A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation" @default.
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• W2979431029 doi "https://doi.org/10.7554/elife.51603" @default.
• W2979431029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6800001" @default.
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• W2979431029 hasPublicationYear "2019" @default.
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