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• W2979431990 abstract "You have accessJournal of UrologySexual Function/Dysfunction: Evaluation II (PD43)1 Apr 2019PD43-11 PREOPERATIVE ERECTILE DYSFUNCTION IS A PROXY OF CHRONIC KIDNEY DISEASE AFTER SURGERY FOR RENAL CELL CARCINOMA - A PILOT STUDY Paolo Capogrosso*, Umberto Capitanio, Alessandro Larcher, Eugenio Ventimiglia, Walter Cazzaniga, Francesco Trevisani, Daniela Canibus, Cristina Carenzi, Franco Gaboardi, Roberto Bertini, Francesco Montorsi, and Andrea Salonia Paolo Capogrosso*Paolo Capogrosso* More articles by this author , Umberto CapitanioUmberto Capitanio More articles by this author , Alessandro LarcherAlessandro Larcher More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Walter CazzanigaWalter Cazzaniga More articles by this author , Francesco TrevisaniFrancesco Trevisani More articles by this author , Daniela CanibusDaniela Canibus More articles by this author , Cristina CarenziCristina Carenzi More articles by this author , Franco GaboardiFranco Gaboardi More articles by this author , Roberto BertiniRoberto Bertini More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556579.46132.5bAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Erectile dysfunction (ED) has been associated with a higher risk of developing cardiovascular diseases, metabolic disorders and other comorbidities. Patients surgically treated for renal cell carcinoma (RCC) are at risk of developing chronic kidney disease (CKD) over time. Detecting those at higher risk of CKD is crucial for an adequate treatment and follow-up planning. We tested the association between preoperative ED and the risk of developing CKD after surgery for RCC. METHODS: A total 106 male patients surgically treated for RCC at a single center, between 2012 and 2018, had available preoperative erectile function (EF) data. Preoperative EF was assessed with the International Index of Erectile Function-EF (IIEF-EF). This questionnaire is routinely administered at our center to RCC patients aged <=70 years. Patients were submitted to either partial (PN) or radical nephrectomy (RN) according to clinical stage. After surgery, they were routinely assessed every 6 months for the first 2 years and annually thereafter; estimated glomerular filtration rate (eGFR) was calculated by the CKD Epidemiology Collaboration formula (CKD-EPI). Patients missing follow-up data were excluded (N=16). Kaplan Meier analyses estimated the cumulative incidence of CKD (eGFR<60 ml/min). Cox regression analyses tested the association between preoperative EF and the risk of postoperative CKD. RESULTS: Median (IQR) preoperative IIEF-EF score was 26 (12-29), with 24% (N=22) of patients reporting scores suggestive for severe ED (IIEF-EF<11). At baseline, 82 (91%) patients had normal eGFR. 55 (61%) patients were treated with RN. Median (IQR) follow-up was 27.5 (17-47) months. Overall, the estimated risk of postoperative CKD was 5% (95%CI: 2-15) and 21% (95%CI: 12-35) at 1- and 2-year after surgery. Patients with preoperative severe ED showed a higher risk (p=0.002) of developing postoperative CKD [1-year: 13% (95%CI: 4-44); 2-year: 44% (95%CI:22-73)] compared to others [1-year: 2%(95%CI: 0-15); 2-year: 13% (95%CI:6-29)]. At Cox regression analysis, preoperative severe ED was associated with higher risk of developing CKD after surgery (HR: 2.67; 95%CI: 1.03-6.94, p=0.04) after adjusting for type of treatment (RN vs. PN) and preoperative eGFR. CONCLUSIONS: Erectile dysfunction is a common disorder among patients with RCC. Those with severe ED depicted 3-fold higher risk of developing postoperative CKD. Preoperative EF status may be an additional factor to be considered for treatment planning and follow-up of patients with RCC. Source of Funding: none Milan, Italy© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e760-e760 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Paolo Capogrosso* More articles by this author Umberto Capitanio More articles by this author Alessandro Larcher More articles by this author Eugenio Ventimiglia More articles by this author Walter Cazzaniga More articles by this author Francesco Trevisani More articles by this author Daniela Canibus More articles by this author Cristina Carenzi More articles by this author Franco Gaboardi More articles by this author Roberto Bertini More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2979431990 title "PD43-11 PREOPERATIVE ERECTILE DYSFUNCTION IS A PROXY OF CHRONIC KIDNEY DISEASE AFTER SURGERY FOR RENAL CELL CARCINOMA - A PILOT STUDY" @default.
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