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• W2979432014 abstract "Tropomyosin is a coiled-coil actin binding protein key to the stability of actin filaments. In muscle cells, tropomyosin is subject to calcium regulation, but its regulation in nonmuscle cells is not understood. Here, we provide evidence that the fission yeast tropomyosin, Cdc8, is regulated by phosphorylation of a serine residue. Failure of phosphorylation leads to an increased number and stability of actin cables and causes misplacement of the division site in certain genetic backgrounds. Phosphorylation of Cdc8 weakens its interaction with actin filaments. Furthermore, we show through in vitro reconstitution that phosphorylation-mediated release of Cdc8 from actin filaments facilitates access of the actin-severing protein Adf1 and subsequent filament disassembly. These studies establish that phosphorylation may be a key mode of regulation of nonmuscle tropomyosins, which in fission yeast controls actin filament stability and division site placement." @default.
• W2979432014 created "2019-10-18" @default.
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• W2979432014 date "2019-10-09" @default.
• W2979432014 modified "2023-10-15" @default.
• W2979432014 title "Phosphoregulation of tropomyosin is crucial for actin cable turnover and division site placement" @default.
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• W2979432014 doi "https://doi.org/10.1083/jcb.201809089" @default.
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