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- W2979464131 abstract "Understanding cell-material interactions requires accurate characterization of the substrate mechanics, which are generally measured by indentation-type atomic force microscopy. To facilitate cell-substrate interaction, model extracellular matrix coatings are used although their tensile mechanical properties are generally unknown. In this study, beyond standard compressive stiffness estimation, we performed a novel tensile mechanical characterization of collagen- and fibronectin-micropatterned polyacrylamide hydrogels. We further demonstrate the impact of the protein mat on the tensile stiffness characterization of adherent cells. To our knowledge, our study is the first to uncover direction-dependent mechanical behavior of the protein coatings and to demonstrate that it affects cellular response relative to substrate mechanics." @default.
- W2979464131 created "2019-10-18" @default.
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- W2979464131 date "2019-10-07" @default.
- W2979464131 modified "2023-10-15" @default.
- W2979464131 title "The Protein Mat(ters)—Revealing the Biologically Relevant Mechanical Contribution of Collagen- and Fibronectin-Coated Micropatterns" @default.
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- W2979464131 doi "https://doi.org/10.1021/acsami.9b12430" @default.
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