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• W2979466076 abstract "Central nervous system complications (CNSCs) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are common and may be a significant source of morbidity and mortality. We performed a retrospective study of 153 pediatric patients who underwent allo-HSCT to determine CNSC type, incidence, and impact on survival. A total of 34 patients (22.2%) developed CNSCs. The cumulative incidence of CNSCs at 100 days and 3 years was 18.30 and 22.73%, respectively. The most common CNSC was calcineurin inhibitor (CNI)-associated neurotoxicity (50.0%). Risk factors for CNSCs were the time from diagnosis to HSCT ≥4.8 months (<i>p</i> = 0.032) and the development of acute graft-versus-host disease (aGVHD) grade III–IV (<i>p</i> = 0.002). CNSCs after allo-HSCT negatively impacted overall survival (hazard ratio [HR] 1.97, <i>p</i> = 0.043) and nonrelapse mortality (HR 4.84, <i>p</i> &#x3c; 0.001). In conclusion, CNSCs after allo-HSCT are associated with poor outcomes; patients with severe aGVHD and/or late transplantation should be given more attention." @default.
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• W2979466076 date "2019-01-01" @default.
• W2979466076 modified "2023-10-14" @default.
• W2979466076 title "Central Nervous System Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children" @default.
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• W2979466076 doi "https://doi.org/10.1159/000499651" @default.
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