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• W2979480498 abstract "Summary Clearance and adaptation to reactive oxygen species (ROS) are crucial for cell survival. As in other eukaryotes, the Neurospora catalases are the main enzymes responsible for ROS clearance and their expression are tightly regulated by the growth and environmental conditions. The RNA polymerase II carboxyl terminal domain (RNAPII CTD) kinase complex (CTK complex) is known as a positive elongation factor for many inducible genes by releasing paused RNAPII near the transcription start site and promoting transcription elongation. However, here we show that deletion of CTK complex components in Neurospora led to high CAT‐3 expression level and resistance to H 2 O 2 ‐induced ROS stress. The catalytic activity of CTK‐1 is required for such a response. On the other hand, CTK‐1 overexpression led to decreased expression of CAT‐3. ChIP assays shows that CTK‐1 phosphorylates the RNAPII CTD at Ser2 residues in the cat‐3 ORF region during transcription elongation and deletion of CTK‐1 led to dramatic decreases of SET‐2 recruitment and H3K36me3 modification. As a result, histones at the cat‐3 locus become hyperacetylated to promote its transcription. Together, these results demonstrate that the CTK complex is negative regulator of cat‐3 expression by affecting its chromatin structure." @default.
• W2979480498 created "2019-10-18" @default.
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• W2979480498 date "2019-10-21" @default.
• W2979480498 modified "2023-10-18" @default.
• W2979480498 title "The <i>Neurospora</i> RNA polymerase II kinase CTK negatively regulates catalase expression in a chromatin context‐dependent manner" @default.
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• W2979480498 doi "https://doi.org/10.1111/1462-2920.14821" @default.
• W2979480498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7216558" @default.
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