FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979484804> ?p ?o ?g. }

• W2979484804 abstract "Abstract Purpose The aim of present study is to measure plasma clozapine (CLZ) and N-desmethyl clozapine (DMC) as biomarkers to correlate drug concentrations with the appearance of preclinical adverse hematic effects. Methods A high-performance liquid chromatographic method, using a diode-array (ultraviolet) detector, was validated to obtain reliable concentrations of CLZ and DMC, its main metabolite, in plasma of 41 schizophrenic patients taking CLZ. Blood neutrophils and leucocytes counting were concurrently assessed as a proxy to subclinical adverse reactions. Results The analytical method employed was linear, reproducible, and stable to measure concentrations of CLZ between 30 and 1000 ng/mL, while 12.5–560 ng/mL of the metabolite. The method allowed us to correlate CLZ plasma concentrations, the time taking CLZ and CLZ dose as determinants of neutrophils’ counting with a R 2 = 0.447, using a multiple regression analysis model. Likewise, the correlation of leucocyte counting vs CLZ plasma levels and CLZ time, showed a R 2 = 0.461. DMC correlated significantly with both neutrophils and leucocytes counting, but was excluded from the regression when CLZ concentration was included in the model. Finally, no other hematological adverse reactions were recorded. One patient presented a cardiovascular complication. The negative correlation between clozapine and neutrophil count observed in patients, suggest that CLZ itself, but not DMC, could be related to hematologic side-effects. Conclusion The findings of this study, demonstrate for the first time, that plasma levels of CLZ and time taking the drug are independent determinants of blood neutrophils and leucocytes, so the monitoring of plasma CLZ may be useful in the clinic practice to determine safe dosing of the drug." @default.
• W2979484804 created "2019-10-18" @default.
• W2979484804 creator A5011592740 @default.
• W2979484804 creator A5018199386 @default.
• W2979484804 creator A5032377993 @default.
• W2979484804 creator A5040168499 @default.
• W2979484804 creator A5048161882 @default.
• W2979484804 creator A5053965578 @default.
• W2979484804 creator A5056771520 @default.
• W2979484804 creator A5076208734 @default.
• W2979484804 date "2019-10-09" @default.
• W2979484804 modified "2023-10-18" @default.
• W2979484804 title "Clozapine and desmethylclozapine: correlation with neutrophils and leucocytes counting in Mexican patients with schizophrenia" @default.
• W2979484804 cites W1501711344 @default.
• W2979484804 cites W1837202277 @default.
• W2979484804 cites W1906444297 @default.
• W2979484804 cites W1963479676 @default.
• W2979484804 cites W1995063674 @default.
• W2979484804 cites W1995868913 @default.
• W2979484804 cites W2036480935 @default.
• W2979484804 cites W2044222389 @default.
• W2979484804 cites W2069024810 @default.
• W2979484804 cites W2078451304 @default.
• W2979484804 cites W2084250773 @default.
• W2979484804 cites W2116693941 @default.
• W2979484804 cites W2135182273 @default.
• W2979484804 cites W2147238434 @default.
• W2979484804 cites W2171300878 @default.
• W2979484804 cites W2222093164 @default.
• W2979484804 cites W227878633 @default.
• W2979484804 cites W2327507814 @default.
• W2979484804 cites W2612895336 @default.
• W2979484804 cites W2756599600 @default.
• W2979484804 cites W2763046479 @default.
• W2979484804 cites W2768290393 @default.
• W2979484804 doi "https://doi.org/10.1186/s12888-019-2286-1" @default.
• W2979484804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6785871" @default.
• W2979484804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31597566" @default.
• W2979484804 hasPublicationYear "2019" @default.
• W2979484804 type Work @default.
• W2979484804 sameAs 2979484804 @default.
• W2979484804 citedByCount "11" @default.
• W2979484804 countsByYear W29794848042019 @default.
• W2979484804 countsByYear W29794848042020 @default.
• W2979484804 countsByYear W29794848042021 @default.
• W2979484804 countsByYear W29794848042022 @default.
• W2979484804 countsByYear W29794848042023 @default.
• W2979484804 crossrefType "journal-article" @default.
• W2979484804 hasAuthorship W2979484804A5011592740 @default.
• W2979484804 hasAuthorship W2979484804A5018199386 @default.
• W2979484804 hasAuthorship W2979484804A5032377993 @default.
• W2979484804 hasAuthorship W2979484804A5040168499 @default.
• W2979484804 hasAuthorship W2979484804A5048161882 @default.
• W2979484804 hasAuthorship W2979484804A5053965578 @default.
• W2979484804 hasAuthorship W2979484804A5056771520 @default.
• W2979484804 hasAuthorship W2979484804A5076208734 @default.
• W2979484804 hasBestOaLocation W29794848041 @default.
• W2979484804 hasConcept C113280763 @default.
• W2979484804 hasConcept C118552586 @default.
• W2979484804 hasConcept C126322002 @default.
• W2979484804 hasConcept C185592680 @default.
• W2979484804 hasConcept C197934379 @default.
• W2979484804 hasConcept C2776412080 @default.
• W2979484804 hasConcept C2777477808 @default.
• W2979484804 hasConcept C2780864610 @default.
• W2979484804 hasConcept C71924100 @default.
• W2979484804 hasConcept C90924648 @default.
• W2979484804 hasConcept C98274493 @default.
• W2979484804 hasConceptScore W2979484804C113280763 @default.
• W2979484804 hasConceptScore W2979484804C118552586 @default.
• W2979484804 hasConceptScore W2979484804C126322002 @default.
• W2979484804 hasConceptScore W2979484804C185592680 @default.
• W2979484804 hasConceptScore W2979484804C197934379 @default.
• W2979484804 hasConceptScore W2979484804C2776412080 @default.
• W2979484804 hasConceptScore W2979484804C2777477808 @default.
• W2979484804 hasConceptScore W2979484804C2780864610 @default.
• W2979484804 hasConceptScore W2979484804C71924100 @default.
• W2979484804 hasConceptScore W2979484804C90924648 @default.
• W2979484804 hasConceptScore W2979484804C98274493 @default.
• W2979484804 hasIssue "1" @default.
• W2979484804 hasLocation W29794848041 @default.
• W2979484804 hasLocation W29794848042 @default.
• W2979484804 hasLocation W29794848043 @default.
• W2979484804 hasLocation W29794848044 @default.
• W2979484804 hasOpenAccess W2979484804 @default.
• W2979484804 hasPrimaryLocation W29794848041 @default.
• W2979484804 hasRelatedWork W1980952315 @default.
• W2979484804 hasRelatedWork W2058372121 @default.
• W2979484804 hasRelatedWork W2144557577 @default.
• W2979484804 hasRelatedWork W2351779880 @default.
• W2979484804 hasRelatedWork W2369295560 @default.
• W2979484804 hasRelatedWork W2748952813 @default.
• W2979484804 hasRelatedWork W2899084033 @default.
• W2979484804 hasRelatedWork W3022989435 @default.
• W2979484804 hasRelatedWork W4238002189 @default.
• W2979484804 hasRelatedWork W4292428568 @default.
• W2979484804 hasVolume "19" @default.
• W2979484804 isParatext "false" @default.
• W2979484804 isRetracted "false" @default.
• W2979484804 magId "2979484804" @default.

• next