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- W2979486590 abstract "Interferons are potent and broadly acting cytokines that stimulate cellular responses to nucleic acids of unusual structures or locations. While protective when induced following viral infections, the induction of interferons is detrimental to the host during L. monocytogenes infection. Here, we identify specific sRNAs, secreted by the bacterium, with the capacity to induce type I IFN. Further analysis of the most potent sRNA, rli32, links the ability to induce RIG-I-dependent induction of the type I IFN response to the intracellular growth properties of the bacterium. Our findings emphasize the significance of released RNA for Listeria infection and shed light on a compartmental strategy used by an intracellular pathogen to modulate host responses to its advantage." @default.
- W2979486590 created "2019-10-18" @default.
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- W2979486590 date "2019-10-29" @default.
- W2979486590 modified "2023-10-16" @default.
- W2979486590 title "The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon" @default.
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- W2979486590 doi "https://doi.org/10.1128/mbio.01223-19" @default.
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