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- W2979486597 endingPage "1523" @default.
- W2979486597 startingPage "1523" @default.
- W2979486597 abstract "Since the clear demonstration of lysophosphatidic acid (LPA)’s pathological roles in cancer in the mid-1990s, more than 1000 papers relating LPA to various types of cancer were published. Through these studies, LPA was established as a target for cancer. Although LPA-related inhibitors entered clinical trials for fibrosis, the concept of targeting LPA is yet to be moved to clinical cancer treatment. The major challenges that we are facing in moving LPA application from bench to bedside include the intrinsic and complicated metabolic, functional, and signaling properties of LPA, as well as technical issues, which are discussed in this review. Potential strategies and perspectives to improve the translational progress are suggested. Despite these challenges, we are optimistic that LPA blockage, particularly in combination with other agents, is on the horizon to be incorporated into clinical applications." @default.
- W2979486597 created "2019-10-18" @default.
- W2979486597 creator A5006567682 @default.
- W2979486597 date "2019-10-10" @default.
- W2979486597 modified "2023-10-16" @default.
- W2979486597 title "Targeting Lysophosphatidic Acid in Cancer: The Issues in Moving from Bench to Bedside" @default.
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