Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979489036> ?p ?o ?g. }
- W2979489036 endingPage "5020" @default.
- W2979489036 startingPage "5020" @default.
- W2979489036 abstract "Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation. In the context of ageing, which is characterized by several physiological alterations leading to a low grade inflammatory status called inflammageing, evidences suggest a potential prolongevity role of probiotics. Unraveling the mechanisms underlying anti-ageing effects requires the use of simple model systems. To this respect, the nematode Caenorhabditis elegans represents a suitable model organism for the study of both host-microbe interactions and for ageing studies, because of conserved signaling pathways and host defense mechanisms involved in the regulation of its lifespan. Therefore, this review analyses the impact of probiotics on C. elegans age-related parameters, with particular emphasis on oxidative stress, immunity, inflammation and protection from pathogen infections. The picture emerging from our analysis highlights that several probiotic strains are able to exert anti-ageing effects in nematodes by acting on common molecular pathways, such as insulin/insulin-like growth factor-1 (IIS) and p38 mitogen-activated protein kinase (p38 MAPK). In this perspective, C. elegans appears to be advantageous for shedding light on key mechanisms involved in host prolongevity in response to probiotics supplementation." @default.
- W2979489036 created "2019-10-18" @default.
- W2979489036 creator A5007148368 @default.
- W2979489036 creator A5043657684 @default.
- W2979489036 creator A5060094345 @default.
- W2979489036 creator A5060333284 @default.
- W2979489036 creator A5078044300 @default.
- W2979489036 creator A5078136691 @default.
- W2979489036 date "2019-10-10" @default.
- W2979489036 modified "2023-10-17" @default.
- W2979489036 title "Caenorhabditis Elegans and Probiotics Interactions from a Prolongevity Perspective" @default.
- W2979489036 cites W1523505474 @default.
- W2979489036 cites W1559542862 @default.
- W2979489036 cites W1944127002 @default.
- W2979489036 cites W1973116767 @default.
- W2979489036 cites W1974738011 @default.
- W2979489036 cites W1990898134 @default.
- W2979489036 cites W1990947933 @default.
- W2979489036 cites W1995008569 @default.
- W2979489036 cites W2002077987 @default.
- W2979489036 cites W2003099302 @default.
- W2979489036 cites W2005181648 @default.
- W2979489036 cites W2009128230 @default.
- W2979489036 cites W2012338704 @default.
- W2979489036 cites W2014707681 @default.
- W2979489036 cites W2015273352 @default.
- W2979489036 cites W2023893313 @default.
- W2979489036 cites W2023923544 @default.
- W2979489036 cites W2023931178 @default.
- W2979489036 cites W2029119914 @default.
- W2979489036 cites W2029945723 @default.
- W2979489036 cites W2036953322 @default.
- W2979489036 cites W2061187463 @default.
- W2979489036 cites W2062591012 @default.
- W2979489036 cites W2063294396 @default.
- W2979489036 cites W2072101365 @default.
- W2979489036 cites W2077180087 @default.
- W2979489036 cites W2080094749 @default.
- W2979489036 cites W2083288132 @default.
- W2979489036 cites W2084630938 @default.
- W2979489036 cites W2088170171 @default.
- W2979489036 cites W2089953620 @default.
- W2979489036 cites W2091944089 @default.
- W2979489036 cites W2098968494 @default.
- W2979489036 cites W2104818214 @default.
- W2979489036 cites W2140296767 @default.
- W2979489036 cites W2144692447 @default.
- W2979489036 cites W2148242921 @default.
- W2979489036 cites W2149074973 @default.
- W2979489036 cites W2152417392 @default.
- W2979489036 cites W2152824815 @default.
- W2979489036 cites W2154438150 @default.
- W2979489036 cites W2162232168 @default.
- W2979489036 cites W2166146113 @default.
- W2979489036 cites W2168390713 @default.
- W2979489036 cites W2174279375 @default.
- W2979489036 cites W2196709866 @default.
- W2979489036 cites W2312624374 @default.
- W2979489036 cites W2314329432 @default.
- W2979489036 cites W2315226266 @default.
- W2979489036 cites W2335974826 @default.
- W2979489036 cites W2345358373 @default.
- W2979489036 cites W2398091551 @default.
- W2979489036 cites W2407890715 @default.
- W2979489036 cites W2434615307 @default.
- W2979489036 cites W2509647828 @default.
- W2979489036 cites W2514435282 @default.
- W2979489036 cites W2522169066 @default.
- W2979489036 cites W2594490647 @default.
- W2979489036 cites W2605968366 @default.
- W2979489036 cites W2727835396 @default.
- W2979489036 cites W2739622235 @default.
- W2979489036 cites W2740311299 @default.
- W2979489036 cites W2745650866 @default.
- W2979489036 cites W2752112633 @default.
- W2979489036 cites W2773578465 @default.
- W2979489036 cites W2774245115 @default.
- W2979489036 cites W2783874580 @default.
- W2979489036 cites W2790178833 @default.
- W2979489036 cites W2794563915 @default.
- W2979489036 cites W2795269621 @default.
- W2979489036 cites W2801881225 @default.
- W2979489036 cites W2809787741 @default.
- W2979489036 cites W2885738092 @default.
- W2979489036 cites W2888531539 @default.
- W2979489036 cites W2892186918 @default.
- W2979489036 cites W2892332370 @default.
- W2979489036 cites W2892587591 @default.
- W2979489036 cites W2895123834 @default.
- W2979489036 cites W2897805071 @default.
- W2979489036 cites W2902784755 @default.
- W2979489036 cites W2903338164 @default.
- W2979489036 cites W2911772452 @default.
- W2979489036 cites W2913653826 @default.
- W2979489036 cites W2915238940 @default.
- W2979489036 cites W2945718218 @default.
- W2979489036 cites W60943716 @default.
- W2979489036 doi "https://doi.org/10.3390/ijms20205020" @default.