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- W2979490003 abstract "Nucleus position in cells can act as a developmental cue. Mammalian oocytes position their nucleus centrally using an F-actin-mediated pressure gradient. The biological significance of nucleus centering in mammalian oocytes being unknown, we sought to assess the F-actin pressure gradient effect on the nucleus. We addressed this using a dedicated computational 3D imaging approach, biophysical analyses, and a nucleus repositioning assay in mouse oocytes mutant for cytoplasmic F-actin. We found that the cytoplasmic activity, in charge of nucleus centering, shaped the nucleus while promoting nuclear envelope fluctuations and chromatin motion. Off-centered nuclei in F-actin mutant oocytes were misshaped with immobile chromatin and modulated gene expression. Restoration of F-actin in mutant oocytes rescued nucleus architecture fully and gene expression partially. Thus, the F-actin-mediated pressure gradient also modulates nucleus dynamics in oocytes. Moreover, this study supports a mechano-transduction model whereby cytoplasmic microfilaments could modulate oocyte transcriptome, essential for subsequent embryo development." @default.
- W2979490003 created "2019-10-18" @default.
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- W2979490003 date "2019-10-01" @default.
- W2979490003 modified "2023-10-15" @default.
- W2979490003 title "Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes" @default.
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- W2979490003 doi "https://doi.org/10.1016/j.devcel.2019.09.010" @default.
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