FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979526968> ?p ?o ?g. }

• W2979526968 endingPage "R802" @default.
• W2979526968 startingPage "R793" @default.
• W2979526968 abstract "Compounds described by humans as “bitter” are sensed by a family of type 2 taste receptors (T2Rs). Previous work suggested that diverse bitter stimuli activate distinct receptors, which might allow for perceptually distinct tastes. Alternatively, it has been shown that multiple T2Rs are expressed on the same taste cell, leading to the contrary suggestion that these stimuli produce a unitary perception. Behavioral work done to address this in rodent models is limited to Spector and Kopka (Spector AC, Kopka SL. J Neurosci 22: 1937–1941, 2002), who demonstrated that rats cannot discriminate quinine from denatonium. Supporting this finding, it has been shown that quinine and denatonium activate overlapping T2Rs and neurons in both the mouse and rat nucleus of the solitary tract (NTS). However, cycloheximide and 6-n-propylthiouracil (PROP) do not appear to overlap with quinine in the NTS, suggesting that these stimuli may be discriminable from quinine and the denatonium/quinine comparison is not generalizable. Using the same procedure as Spector and Kopka, we tasked animals with discriminating a range of stimuli (denatonium, cycloheximide, PROP, and sucrose octaacetate) from quinine. We replicated and expanded the findings of Spector and Kopka; rats could not discriminate quinine from denatonium, cycloheximide, or PROP. Rats showed a very weak ability to discriminate between quinine and sucrose octaacetate. All animals succeeded in discriminating quinine from KCl, demonstrating they were capable of the task. These data suggest that rats cannot discriminate this suite of stimuli, although they appear distinct by physiological measures." @default.
• W2979526968 created "2019-10-18" @default.
• W2979526968 creator A5014744090 @default.
• W2979526968 creator A5039733800 @default.
• W2979526968 creator A5043008741 @default.
• W2979526968 date "2019-12-01" @default.
• W2979526968 modified "2023-09-24" @default.
• W2979526968 title "Rats are unable to discriminate quinine from diverse bitter stimuli" @default.
• W2979526968 cites W1496676716 @default.
• W2979526968 cites W1966892082 @default.
• W2979526968 cites W1973693850 @default.
• W2979526968 cites W1974966177 @default.
• W2979526968 cites W1978990274 @default.
• W2979526968 cites W1980409809 @default.
• W2979526968 cites W1981803005 @default.
• W2979526968 cites W1990093807 @default.
• W2979526968 cites W1991550423 @default.
• W2979526968 cites W2002516706 @default.
• W2979526968 cites W2015171742 @default.
• W2979526968 cites W2025270961 @default.
• W2979526968 cites W2043299418 @default.
• W2979526968 cites W2057249870 @default.
• W2979526968 cites W2071196106 @default.
• W2979526968 cites W2072794808 @default.
• W2979526968 cites W2077395698 @default.
• W2979526968 cites W2082269792 @default.
• W2979526968 cites W2089885047 @default.
• W2979526968 cites W2094710909 @default.
• W2979526968 cites W2101756413 @default.
• W2979526968 cites W2102837616 @default.
• W2979526968 cites W2105678614 @default.
• W2979526968 cites W2110147039 @default.
• W2979526968 cites W2114742945 @default.
• W2979526968 cites W2118311495 @default.
• W2979526968 cites W2124347793 @default.
• W2979526968 cites W2129988654 @default.
• W2979526968 cites W2136067579 @default.
• W2979526968 cites W2137311570 @default.
• W2979526968 cites W2138727998 @default.
• W2979526968 cites W2145126181 @default.
• W2979526968 cites W2152729961 @default.
• W2979526968 cites W2171334005 @default.
• W2979526968 cites W2254661489 @default.
• W2979526968 cites W2260182572 @default.
• W2979526968 cites W2264657430 @default.
• W2979526968 cites W2282463192 @default.
• W2979526968 cites W2330839345 @default.
• W2979526968 cites W2398160652 @default.
• W2979526968 cites W2885353999 @default.
• W2979526968 cites W2931492092 @default.
• W2979526968 cites W2941921899 @default.
• W2979526968 cites W4253916732 @default.
• W2979526968 doi "https://doi.org/10.1152/ajpregu.00213.2019" @default.
• W2979526968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6957374" @default.
• W2979526968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31596113" @default.
• W2979526968 hasPublicationYear "2019" @default.
• W2979526968 type Work @default.
• W2979526968 sameAs 2979526968 @default.
• W2979526968 citedByCount "3" @default.
• W2979526968 countsByYear W29795269682020 @default.
• W2979526968 countsByYear W29795269682021 @default.
• W2979526968 countsByYear W29795269682023 @default.
• W2979526968 crossrefType "journal-article" @default.
• W2979526968 hasAuthorship W2979526968A5014744090 @default.
• W2979526968 hasAuthorship W2979526968A5039733800 @default.
• W2979526968 hasAuthorship W2979526968A5043008741 @default.
• W2979526968 hasBestOaLocation W29795269681 @default.
• W2979526968 hasConcept C169760540 @default.
• W2979526968 hasConcept C185592680 @default.
• W2979526968 hasConcept C203014093 @default.
• W2979526968 hasConcept C2777617192 @default.
• W2979526968 hasConcept C2778048844 @default.
• W2979526968 hasConcept C2778128677 @default.
• W2979526968 hasConcept C3675279 @default.
• W2979526968 hasConcept C55493867 @default.
• W2979526968 hasConcept C86803240 @default.
• W2979526968 hasConcept C8868529 @default.
• W2979526968 hasConcept C98274493 @default.
• W2979526968 hasConceptScore W2979526968C169760540 @default.
• W2979526968 hasConceptScore W2979526968C185592680 @default.
• W2979526968 hasConceptScore W2979526968C203014093 @default.
• W2979526968 hasConceptScore W2979526968C2777617192 @default.
• W2979526968 hasConceptScore W2979526968C2778048844 @default.
• W2979526968 hasConceptScore W2979526968C2778128677 @default.
• W2979526968 hasConceptScore W2979526968C3675279 @default.
• W2979526968 hasConceptScore W2979526968C55493867 @default.
• W2979526968 hasConceptScore W2979526968C86803240 @default.
• W2979526968 hasConceptScore W2979526968C8868529 @default.
• W2979526968 hasConceptScore W2979526968C98274493 @default.
• W2979526968 hasFunder F4320337352 @default.
• W2979526968 hasIssue "6" @default.
• W2979526968 hasLocation W29795269681 @default.
• W2979526968 hasLocation W29795269682 @default.
• W2979526968 hasLocation W29795269683 @default.
• W2979526968 hasOpenAccess W2979526968 @default.
• W2979526968 hasPrimaryLocation W29795269681 @default.
• W2979526968 hasRelatedWork W1969932055 @default.
• W2979526968 hasRelatedWork W1970959092 @default.

• next