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• W2979530804 abstract "Disorders affecting sleep and the circadian rhythm, autonomic clinical signs and symptoms, and neuroendocrine alterations are frequent characteristics in Huntington's disease, some of which present in early stages of the disease. It is reasonable to think that some of these features could result from a hypothalamic dysfunction affecting the centre regulating sleep, metabolism and the autonomic nervous system.The study presents the evidence available to date that suggests the involvement of a hypothalamic disorder in Huntington's disease.Histopathological, hormonal and neuroimaging research relates this area of the brain to Huntington's disease. The experimental findings and those obtained with animal models or in studies conducted with patients are summarised. Likewise, the clinical repercussions (sleep and circadian rhythm disorders, psychiatric and cognitive pathologies, and the clinical signs and symptoms linked to autonomic dysfunction) secondary to possible involvement of the hypothalamus in this disease are also described.The hypothalamus acts as a centre that integrates the neuroendocrine and autonomic functions, and plays a significant role in cognitive and behavioural signs and symptoms. Disorders of this type have been highlighted in Huntington's disease. Further studies are needed to elucidate the role and scope of this region of the brain in this disease.El hipotalamo en la enfermedad de Huntington.Introduccion. Los trastornos del sueño y del ritmo circadiano, la sintomatologia autonomica y las alteraciones neuroendocrinas son caracteristicas frecuentes de la enfermedad de Huntington, y algunos de ellos se presentan en estadios tempranos de ella. Es plausible pensar que algunos de estos rasgos podrian ser el resultado de una disfuncion hipotalamica del centro regulador del sueño, el metabolismo y el sistema nervioso autonomo. Objetivo. Se exponen las evidencias disponibles hasta el momento actual que sugieren una afectacion hipotalamica en la enfermedad de Huntington. Desarrollo. Investigaciones histopatologicas, hormonales y de neuroimagen relacionan esta region cerebral con la enfermedad de Huntington. Se resumen los hallazgos, tanto experimentales como en modelos animales, o en estudios realizados con pacientes. Asimismo, se describen las repercusiones clinicas (alteraciones del sueño y del ritmo circadiano, la patologia psiquiatrica y cognitiva, y la clinica vinculada con disfuncion autonomica) secundarias a una posible afectacion hipotalamica en esta enfermedad. Conclusiones. El hipotalamo se comporta como un centro integrador de las funciones neuroendocrinas y autonomicas, y presenta un papel no desdeñable sobre la sintomatologia cognitiva y conductual. Alteraciones al respecto se han destacado en la enfermedad de Huntington. Son necesarios posteriores estudios para aclarar el papel y el alcance de esta region cerebral en esta enfermedad." @default.
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• W2979530804 date "2017-01-01" @default.
• W2979530804 modified "2023-09-28" @default.
• W2979530804 title "El hipotálamo en la enfermedad de Huntington" @default.
• W2979530804 doi "https://doi.org/10.33588/rn.6509.2017066" @default.
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