Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979552246> ?p ?o ?g. }
- W2979552246 endingPage "468" @default.
- W2979552246 startingPage "455" @default.
- W2979552246 abstract "Abstract Ribosomal protein (RP) genes encode structural components of ribosomes, the cellular machinery for protein synthesis. A single functional copy has been maintained in most of 78–80 RP families in animals due to evolutionary constraints imposed by gene dosage balance. Some fungal species have maintained duplicate copies in most RP families. The mechanisms by which the RP genes were duplicated and maintained and their functional significance are poorly understood. To address these questions, we identified all RP genes from 295 fungi and inferred the timing and nature of gene duplication events for all RP families. We found that massive duplications of RP genes have independently occurred by different mechanisms in three distantly related lineages: budding yeasts, fission yeasts, and Mucoromycota. The RP gene duplicates in budding yeasts and Mucoromycota were mainly created by whole genome duplication events. However, duplicate RP genes in fission yeasts were likely generated by retroposition, which is unexpected considering their dosage sensitivity. The sequences of most RP paralogs have been homogenized by repeated gene conversion in each species, demonstrating parallel concerted evolution, which might have facilitated the retention of their duplicates. Transcriptomic data suggest that the duplication and retention of RP genes increased their transcript abundance. Physiological data indicate that increased ribosome biogenesis allowed these organisms to rapidly consume sugars through fermentation while maintaining high growth rates, providing selective advantages to these species in sugar-rich environments." @default.
- W2979552246 created "2019-10-18" @default.
- W2979552246 creator A5017057419 @default.
- W2979552246 creator A5018247973 @default.
- W2979552246 creator A5023732216 @default.
- W2979552246 creator A5024425081 @default.
- W2979552246 creator A5044172740 @default.
- W2979552246 creator A5044412187 @default.
- W2979552246 creator A5068053666 @default.
- W2979552246 creator A5076594482 @default.
- W2979552246 date "2019-10-07" @default.
- W2979552246 modified "2023-10-12" @default.
- W2979552246 title "Parallel Concerted Evolution of Ribosomal Protein Genes in Fungi and Its Adaptive Significance" @default.
- W2979552246 cites W136933060 @default.
- W2979552246 cites W1641544182 @default.
- W2979552246 cites W1901476197 @default.
- W2979552246 cites W1964612763 @default.
- W2979552246 cites W1968281356 @default.
- W2979552246 cites W1970070225 @default.
- W2979552246 cites W1971231926 @default.
- W2979552246 cites W1976445111 @default.
- W2979552246 cites W1979612739 @default.
- W2979552246 cites W1981195576 @default.
- W2979552246 cites W1982197590 @default.
- W2979552246 cites W1991925880 @default.
- W2979552246 cites W1997088865 @default.
- W2979552246 cites W2005319444 @default.
- W2979552246 cites W2018486257 @default.
- W2979552246 cites W2024675966 @default.
- W2979552246 cites W2028190503 @default.
- W2979552246 cites W2036726333 @default.
- W2979552246 cites W2041854849 @default.
- W2979552246 cites W2045968140 @default.
- W2979552246 cites W2047195788 @default.
- W2979552246 cites W2047484972 @default.
- W2979552246 cites W2049883153 @default.
- W2979552246 cites W2052906061 @default.
- W2979552246 cites W2054755820 @default.
- W2979552246 cites W2069189464 @default.
- W2979552246 cites W2069459256 @default.
- W2979552246 cites W2079197003 @default.
- W2979552246 cites W2079318906 @default.
- W2979552246 cites W2080882866 @default.
- W2979552246 cites W2081840182 @default.
- W2979552246 cites W2081933515 @default.
- W2979552246 cites W2084403139 @default.
- W2979552246 cites W2086015868 @default.
- W2979552246 cites W2088127501 @default.
- W2979552246 cites W2089734621 @default.
- W2979552246 cites W2091876911 @default.
- W2979552246 cites W2094454681 @default.
- W2979552246 cites W2098066769 @default.
- W2979552246 cites W2098599292 @default.
- W2979552246 cites W2103111028 @default.
- W2979552246 cites W2103581172 @default.
- W2979552246 cites W2103924273 @default.
- W2979552246 cites W2104306559 @default.
- W2979552246 cites W2104308520 @default.
- W2979552246 cites W2109537731 @default.
- W2979552246 cites W2109717569 @default.
- W2979552246 cites W2110519885 @default.
- W2979552246 cites W2115964553 @default.
- W2979552246 cites W2116516380 @default.
- W2979552246 cites W2119966574 @default.
- W2979552246 cites W2125559940 @default.
- W2979552246 cites W2127028479 @default.
- W2979552246 cites W2130412392 @default.
- W2979552246 cites W2132926880 @default.
- W2979552246 cites W2134153749 @default.
- W2979552246 cites W2141439014 @default.
- W2979552246 cites W2142678478 @default.
- W2979552246 cites W2144654387 @default.
- W2979552246 cites W2144893438 @default.
- W2979552246 cites W2147402993 @default.
- W2979552246 cites W2151621071 @default.
- W2979552246 cites W2157406319 @default.
- W2979552246 cites W2158180844 @default.
- W2979552246 cites W2160876388 @default.
- W2979552246 cites W2162528766 @default.
- W2979552246 cites W2165418074 @default.
- W2979552246 cites W2168608639 @default.
- W2979552246 cites W2168627344 @default.
- W2979552246 cites W2168696662 @default.
- W2979552246 cites W2171313861 @default.
- W2979552246 cites W2172296079 @default.
- W2979552246 cites W2275478399 @default.
- W2979552246 cites W2311203695 @default.
- W2979552246 cites W2403493353 @default.
- W2979552246 cites W2474525766 @default.
- W2979552246 cites W2506030147 @default.
- W2979552246 cites W2804483100 @default.
- W2979552246 cites W2907899595 @default.
- W2979552246 cites W4229487902 @default.
- W2979552246 cites W798940297 @default.
- W2979552246 doi "https://doi.org/10.1093/molbev/msz229" @default.
- W2979552246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6993855" @default.
- W2979552246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31589316" @default.
- W2979552246 hasPublicationYear "2019" @default.