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- W2979578775 abstract "Methylated flavonoids possess improved bioactivities compared to their unmethylated counterparts. In this study, for the efficient production of O-methylated flavonoids from simple methylated phenylpropanoic acids, a recombinant Escherichia coli strain expressing 4-coumarate:coenzyme A ligase (4CL) from Oryza sativa and chalcone synthase (CHS) from Hordeum vulgare was constructed; this strain produced significant amount of homoeriodictyol (~ 52 mg/L) as well as a few amount of hesperetin (0.4 mg/L), respectively, from ferulic acid and 4-methylcaffeic acid. This demonstrates, for the first time, that the scarce but valuable methylated flavanones can be successfully produced from methylated phenylpropanoic acids in a microbial host via an artificial biosynthetic pathway consisting of 4CL and CHS that can accept O-methylated precursors." @default.
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- W2979578775 date "2019-12-01" @default.
- W2979578775 modified "2023-10-15" @default.
- W2979578775 title "Microbial production of <i>O</i>-methylated flavanones from methylated phenylpropanoic acids in engineered <i>Escherichia coli</i>" @default.
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- W2979578775 doi "https://doi.org/10.1007/s10295-019-02239-6" @default.
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