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- W2979583542 endingPage "1515" @default.
- W2979583542 startingPage "1515" @default.
- W2979583542 abstract "DNA methylation is the most widely-studied epigenetic modification, playing a critical role in the regulation of gene expression. Dysregulation of DNA methylation is implicated in the pathogenesis of numerous diseases. For example, aberrant DNA methylation in promoter regions of tumor-suppressor genes has been strongly associated with the development and progression of many different tumors. Accordingly, technologies designed to manipulate DNA methylation at specific genomic loci are very important, especially in the context of cancer therapy. Traditionally, epigenomic editing technologies have centered around zinc finger proteins (ZFP)- and transcription activator-like effector protein (TALE)-based targeting. More recently, however, the emergence of clustered regulatory interspaced short palindromic repeats (CRISPR)-deactivated Cas9 (dCas9)-based editing systems have shown to be a more specific and efficient method for the targeted manipulation of DNA methylation. Here, we describe the regulation of the DNA methylome, its significance in cancer and the current state of locus-specific editing technologies for altering DNA methylation." @default.
- W2979583542 created "2019-10-18" @default.
- W2979583542 creator A5005960789 @default.
- W2979583542 creator A5009649448 @default.
- W2979583542 creator A5042462309 @default.
- W2979583542 creator A5044484080 @default.
- W2979583542 date "2019-10-09" @default.
- W2979583542 modified "2023-10-15" @default.
- W2979583542 title "Gene-Specific Targeting of DNA Methylation in the Mammalian Genome" @default.
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