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- W2979583665 abstract "The clinical development of cancer drugs is rapidly moving from empirical one drug fits all or development-by-tumor-type approaches towards more personalized treatment models. A deeper understanding of cancer and the immune system, novel technologies, and powerful analytics have fueled an increase in precision oncology approaches integrating the molecular profiles of the tumor with the clinical profile of the patient. While this approach has been successful for targeted therapies, the complex mode of action of immunotherapies will likely require integration of clinical profiling with more comprehensive profiling of the tumor, of the tumor microenvironment, and of the immune system of the patient. Integration of precision oncology into clinical research for immunotherapies is viewed as a means to better select patients in the early clinical phase of drug development to (1) maximize the benefit-to-risk ratio for the patient, (2) generate early proof of concept and proof of relevance for the investigational drug, and (3) inform on how to best combine or sequence the therapeutic with other drugs. Here we discuss the upsides and challenges of incorporating precision immuno-oncology into early-phase clinical trials." @default.
- W2979583665 created "2019-10-18" @default.
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- W2979583665 date "2019-10-08" @default.
- W2979583665 modified "2023-09-28" @default.
- W2979583665 title "Precision Oncology for Cancer Immunotherapies in Early-Phase Clinical Trials" @default.
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- W2979583665 doi "https://doi.org/10.1007/s11523-019-00678-w" @default.
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