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- W2979587573 abstract "Mutations have a profound effect on human health, particularly through an increased risk of carcinogenesis and genetic disease. The strong correlation between mutagenesis and carcinogenesis has been a driving force behind genotoxicity research for more than 50 years. The stochastic and infrequent nature of mutagenesis makes it challenging to observe and to study. Indeed, decades have been spent developing increasingly sophisticated assays and methods to study these low-frequency genetic errors, in hopes of better predicting which chemicals may be carcinogens, understanding their mode of action, and informing guidelines to prevent undue human exposure. While effective, widely used genetic selection-based technologies have a number of limitations that have hampered major advancements in the field of genotoxicity. Emerging new tools, in the form of enhanced next-generation sequencing platforms and methods, are changing this paradigm. In this review, we discuss rapidly evolving sequencing tools and technologies, such as error-corrected sequencing and single cell analysis, which we anticipate will fundamentally reshape the field. In addition, we consider a variety emerging applications for these new technologies, including the detection of DNA adducts, inference of mutational processes based on genomic site and local sequence contexts, and evaluation of genome engineering fidelity, as well as other cutting-edge challenges for the next 50 years of environmental and molecular mutagenesis research. Environ. Mol. Mutagen. 61:135-151, 2020. © 2019 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society." @default.
- W2979587573 created "2019-10-18" @default.
- W2979587573 creator A5024041027 @default.
- W2979587573 creator A5054082017 @default.
- W2979587573 date "2019-11-11" @default.
- W2979587573 modified "2023-10-15" @default.
- W2979587573 title "Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk" @default.
- W2979587573 cites W1492083415 @default.
- W2979587573 cites W1533712488 @default.
- W2979587573 cites W1569060300 @default.
- W2979587573 cites W1841351562 @default.
- W2979587573 cites W1950829641 @default.
- W2979587573 cites W1956871134 @default.
- W2979587573 cites W1957977360 @default.
- W2979587573 cites W1964807436 @default.
- W2979587573 cites W1971584645 @default.
- W2979587573 cites W1975384402 @default.
- W2979587573 cites W1976917904 @default.
- W2979587573 cites W1989298969 @default.
- W2979587573 cites W1996813968 @default.
- W2979587573 cites W1997281938 @default.
- W2979587573 cites W1997666780 @default.
- W2979587573 cites W1999790790 @default.
- W2979587573 cites W2003797386 @default.
- W2979587573 cites W2004053511 @default.
- W2979587573 cites W2007772656 @default.
- W2979587573 cites W2008269929 @default.
- W2979587573 cites W2010977820 @default.
- W2979587573 cites W2011645981 @default.
- W2979587573 cites W2016966302 @default.
- W2979587573 cites W2017004978 @default.
- W2979587573 cites W2022642195 @default.
- W2979587573 cites W2031191277 @default.
- W2979587573 cites W2031982698 @default.
- W2979587573 cites W2032518018 @default.
- W2979587573 cites W2034325392 @default.
- W2979587573 cites W2036216041 @default.
- W2979587573 cites W2044391097 @default.
- W2979587573 cites W2055548328 @default.
- W2979587573 cites W2064977507 @default.
- W2979587573 cites W2067951632 @default.
- W2979587573 cites W2073105380 @default.
- W2979587573 cites W2073276461 @default.
- W2979587573 cites W2077224253 @default.
- W2979587573 cites W2077659966 @default.
- W2979587573 cites W2083870688 @default.
- W2979587573 cites W2091427225 @default.
- W2979587573 cites W2092772380 @default.
- W2979587573 cites W2095301528 @default.
- W2979587573 cites W2095763520 @default.
- W2979587573 cites W2097960607 @default.
- W2979587573 cites W2102752109 @default.
- W2979587573 cites W2111179781 @default.
- W2979587573 cites W2112444085 @default.
- W2979587573 cites W2113002917 @default.
- W2979587573 cites W2114632170 @default.
- W2979587573 cites W2118526609 @default.
- W2979587573 cites W2119278037 @default.
- W2979587573 cites W2122573972 @default.
- W2979587573 cites W2122959256 @default.
- W2979587573 cites W2124715997 @default.
- W2979587573 cites W2126466006 @default.
- W2979587573 cites W2129787793 @default.
- W2979587573 cites W2130954387 @default.
- W2979587573 cites W2133385595 @default.
- W2979587573 cites W2133676450 @default.
- W2979587573 cites W2134259738 @default.
- W2979587573 cites W2134429697 @default.
- W2979587573 cites W2134566370 @default.
- W2979587573 cites W2134976660 @default.
- W2979587573 cites W2135937351 @default.
- W2979587573 cites W2140291328 @default.
- W2979587573 cites W2143197030 @default.
- W2979587573 cites W2143513584 @default.
- W2979587573 cites W2147533120 @default.
- W2979587573 cites W2152061559 @default.
- W2979587573 cites W2152241467 @default.
- W2979587573 cites W2160225487 @default.
- W2979587573 cites W2162116127 @default.
- W2979587573 cites W2173751778 @default.
- W2979587573 cites W2173818354 @default.
- W2979587573 cites W2324637511 @default.
- W2979587573 cites W2341025815 @default.
- W2979587573 cites W2346663063 @default.
- W2979587573 cites W2346680365 @default.
- W2979587573 cites W2410046771 @default.
- W2979587573 cites W2462180542 @default.
- W2979587573 cites W2505939414 @default.
- W2979587573 cites W2510475044 @default.
- W2979587573 cites W2519955476 @default.
- W2979587573 cites W2524881570 @default.
- W2979587573 cites W2526788217 @default.
- W2979587573 cites W2580989000 @default.
- W2979587573 cites W2588569583 @default.
- W2979587573 cites W2597577045 @default.
- W2979587573 cites W2598149992 @default.
- W2979587573 cites W2605512081 @default.
- W2979587573 cites W2605826110 @default.