FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979589768> ?p ?o ?g. }

• W2979589768 endingPage "149" @default.
• W2979589768 startingPage "149" @default.
• W2979589768 abstract ": Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, and it exhibits resistance to common breast cancer therapies. Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1) and its ligand, PD-L1, have been approved to treat various cancers. However, the therapeutic efficacy of targeting PD-1/PD-L1 axis in breast cancer is under clinical investigation. In addition, the mechanisms of action of drugs targeting PD-1 and PD-L1 have not been fully elucidated. In this study, we investigated the effect of human TNBC cell lines, MDA-MB-231 and MDA-MB-468, and the non-TNBC cell line, MCF-7, on the expression of immune checkpoints (ICs) on CD4+ T cell subsets, including regulatory T cells (Tregs), using a co-culture system. We also examined the effect of blocking PD-1 or PD-L1 separately and in combination on IC expression by CD4+ T cell subsets. We found that breast cancer cells upregulate the expression of ICs including PD-1, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and lymphocyte activation gene-3 (LAG-3) in CD4+ T cell subsets. We also found that the co-blockade of PD-1 and PD-L1 further upregulates the co-expression of TIM-3 and LAG-3 on CD4+CD25+ T cells and CD4+CD25+FoxP3+Helios+ Tregs in the presence of TNBC cells, but not in non-TNBC cells. Our results indicate the emergence of compensatory inhibitory mechanisms, most likely mediated by Tregs and activated non-Tregs, which could lead to the development of TNBC resistance against PD-1/PD-L1 blockade." @default.
• W2979589768 created "2019-10-18" @default.
• W2979589768 creator A5000534833 @default.
• W2979589768 creator A5017492246 @default.
• W2979589768 creator A5062972032 @default.
• W2979589768 creator A5071005652 @default.
• W2979589768 date "2019-10-12" @default.
• W2979589768 modified "2023-10-17" @default.
• W2979589768 title "Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4+ T Cells" @default.
• W2979589768 cites W1540592014 @default.
• W2979589768 cites W1587652097 @default.
• W2979589768 cites W1910012553 @default.
• W2979589768 cites W1945928767 @default.
• W2979589768 cites W1984909066 @default.
• W2979589768 cites W1994238092 @default.
• W2979589768 cites W2044702943 @default.
• W2979589768 cites W2057186227 @default.
• W2979589768 cites W2063264144 @default.
• W2979589768 cites W2072213835 @default.
• W2979589768 cites W2072853625 @default.
• W2979589768 cites W2097255042 @default.
• W2979589768 cites W2097811455 @default.
• W2979589768 cites W2099175643 @default.
• W2979589768 cites W2100083914 @default.
• W2979589768 cites W2100413206 @default.
• W2979589768 cites W2104347254 @default.
• W2979589768 cites W2111225997 @default.
• W2979589768 cites W2115918781 @default.
• W2979589768 cites W2131994307 @default.
• W2979589768 cites W2134539328 @default.
• W2979589768 cites W2147968481 @default.
• W2979589768 cites W2151293773 @default.
• W2979589768 cites W2170602872 @default.
• W2979589768 cites W2178643122 @default.
• W2979589768 cites W2259802687 @default.
• W2979589768 cites W2329974159 @default.
• W2979589768 cites W2371138393 @default.
• W2979589768 cites W2509486054 @default.
• W2979589768 cites W2515876677 @default.
• W2979589768 cites W2544675721 @default.
• W2979589768 cites W2554479252 @default.
• W2979589768 cites W2560367415 @default.
• W2979589768 cites W2560827811 @default.
• W2979589768 cites W2572174216 @default.
• W2979589768 cites W2619600619 @default.
• W2979589768 cites W2765354611 @default.
• W2979589768 cites W2769545617 @default.
• W2979589768 cites W2782676239 @default.
• W2979589768 cites W2794612508 @default.
• W2979589768 cites W2799532768 @default.
• W2979589768 cites W2805900947 @default.
• W2979589768 cites W2809982613 @default.
• W2979589768 cites W2884397271 @default.
• W2979589768 cites W2888240339 @default.
• W2979589768 cites W2904382186 @default.
• W2979589768 cites W2911188335 @default.
• W2979589768 cites W2937318637 @default.
• W2979589768 cites W2944786442 @default.
• W2979589768 cites W2947477779 @default.
• W2979589768 cites W2952815301 @default.
• W2979589768 cites W2953813865 @default.
• W2979589768 cites W2965067427 @default.
• W2979589768 doi "https://doi.org/10.3390/vaccines7040149" @default.
• W2979589768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6963740" @default.
• W2979589768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31614877" @default.
• W2979589768 hasPublicationYear "2019" @default.
• W2979589768 type Work @default.
• W2979589768 sameAs 2979589768 @default.
• W2979589768 citedByCount "57" @default.
• W2979589768 countsByYear W29795897682020 @default.
• W2979589768 countsByYear W29795897682021 @default.
• W2979589768 countsByYear W29795897682022 @default.
• W2979589768 countsByYear W29795897682023 @default.
• W2979589768 crossrefType "journal-article" @default.
• W2979589768 hasAuthorship W2979589768A5000534833 @default.
• W2979589768 hasAuthorship W2979589768A5017492246 @default.
• W2979589768 hasAuthorship W2979589768A5062972032 @default.
• W2979589768 hasAuthorship W2979589768A5071005652 @default.
• W2979589768 hasBestOaLocation W29795897681 @default.
• W2979589768 hasConcept C121608353 @default.
• W2979589768 hasConcept C126322002 @default.
• W2979589768 hasConcept C154317977 @default.
• W2979589768 hasConcept C202751555 @default.
• W2979589768 hasConcept C203014093 @default.
• W2979589768 hasConcept C21705690 @default.
• W2979589768 hasConcept C2776090121 @default.
• W2979589768 hasConcept C2777701055 @default.
• W2979589768 hasConcept C2779727006 @default.
• W2979589768 hasConcept C2780110267 @default.
• W2979589768 hasConcept C2780851360 @default.
• W2979589768 hasConcept C2781053074 @default.
• W2979589768 hasConcept C502942594 @default.
• W2979589768 hasConcept C530470458 @default.
• W2979589768 hasConcept C55493867 @default.
• W2979589768 hasConcept C71924100 @default.
• W2979589768 hasConcept C79484868 @default.
• W2979589768 hasConcept C86803240 @default.
• W2979589768 hasConcept C8891405 @default.

• next