FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979610535> ?p ?o ?g. }

• W2979610535 endingPage "199" @default.
• W2979610535 startingPage "192" @default.
• W2979610535 abstract "Neuro-inflammation might impact on clinical manifestations and cognition function via changing the volumes of key brain structures such as the anterior cingulate cortex (ACC) in bipolar disorder (BD). In this study, we investigated the interrelations among interleukin (IL)-6 cytokine level, grey matter (GM) volume of the anterior cingulated cortex (ACC), and attention function among offspring of parents diagnosed with BD. The offspring were categorized as being either asymptomatic or symptomatic based on whether they manifested pre-defined sub-threshold mood symptoms. We found that the symptomatic offspring showed significantly higher serum levels of IL-6 than the asymptomatic offspring (F(1, 59) = 67.65, p < 0.001). On the brain level, we obtained significant interactive effect of group and IL6 level on the ACC GM (PFWE = 0.017). Specifically, the GM volume of the rostral ACC was negatively associated with the levels of IL-6 in the asymptomatic offspring (PFWE = 0.021), but not the symptomatic offspring (PFWE > 0.05). Mediation analyses revealed that the GM volume of the rostral ACC significantly mediated the negative association between the IL-6 levels and attention performance in the asymptomatic offspring (bootstrapping Confidence Interval (CI) = −6.0432 to −0.0731) but not the symptomatic offspring (bootstrapping CI = −0.3197 to 1.3423). Our data suggest that the asymptomatic and symptomatic bipolar offspring may exhibit different neurocognitive-inflammatory profiles, which could be further validated as viable biosignatures for BD risk and resilience." @default.
• W2979610535 created "2019-10-18" @default.
• W2979610535 creator A5005434770 @default.
• W2979610535 creator A5012250982 @default.
• W2979610535 creator A5023720185 @default.
• W2979610535 creator A5032613018 @default.
• W2979610535 creator A5035411450 @default.
• W2979610535 creator A5038435667 @default.
• W2979610535 creator A5051815938 @default.
• W2979610535 creator A5053894247 @default.
• W2979610535 creator A5064374185 @default.
• W2979610535 creator A5066716873 @default.
• W2979610535 creator A5068594039 @default.
• W2979610535 creator A5068850044 @default.
• W2979610535 creator A5069408326 @default.
• W2979610535 creator A5076331964 @default.
• W2979610535 creator A5078988597 @default.
• W2979610535 date "2020-01-01" @default.
• W2979610535 modified "2023-10-01" @default.
• W2979610535 title "Inflammation, brain structure and cognition interrelations among individuals with differential risks for bipolar disorder" @default.
• W2979610535 cites W1582811168 @default.
• W2979610535 cites W1767580214 @default.
• W2979610535 cites W1844122334 @default.
• W2979610535 cites W1904092541 @default.
• W2979610535 cites W1964555614 @default.
• W2979610535 cites W1969699052 @default.
• W2979610535 cites W1973125755 @default.
• W2979610535 cites W1980756087 @default.
• W2979610535 cites W1983960867 @default.
• W2979610535 cites W1989369404 @default.
• W2979610535 cites W1991156858 @default.
• W2979610535 cites W1992973534 @default.
• W2979610535 cites W2006418886 @default.
• W2979610535 cites W2006473634 @default.
• W2979610535 cites W2012930576 @default.
• W2979610535 cites W2014858274 @default.
• W2979610535 cites W2016883790 @default.
• W2979610535 cites W2019604064 @default.
• W2979610535 cites W2021437265 @default.
• W2979610535 cites W2024839488 @default.
• W2979610535 cites W2031329056 @default.
• W2979610535 cites W2032117526 @default.
• W2979610535 cites W2038702827 @default.
• W2979610535 cites W2059834362 @default.
• W2979610535 cites W2079969863 @default.
• W2979610535 cites W2086234351 @default.
• W2979610535 cites W2090813996 @default.
• W2979610535 cites W2101209751 @default.
• W2979610535 cites W2109010008 @default.
• W2979610535 cites W2110959633 @default.
• W2979610535 cites W2116210000 @default.
• W2979610535 cites W2124406767 @default.
• W2979610535 cites W2124979499 @default.
• W2979610535 cites W2128499731 @default.
• W2979610535 cites W2146726024 @default.
• W2979610535 cites W2155298532 @default.
• W2979610535 cites W2155574232 @default.
• W2979610535 cites W2156241207 @default.
• W2979610535 cites W2159838806 @default.
• W2979610535 cites W2165520691 @default.
• W2979610535 cites W2196461303 @default.
• W2979610535 cites W2293546053 @default.
• W2979610535 cites W2312324554 @default.
• W2979610535 cites W2336065669 @default.
• W2979610535 cites W2411997747 @default.
• W2979610535 cites W2414600137 @default.
• W2979610535 cites W2540039596 @default.
• W2979610535 cites W2557456288 @default.
• W2979610535 cites W2567310514 @default.
• W2979610535 cites W2585331687 @default.
• W2979610535 cites W2598220081 @default.
• W2979610535 cites W2613405343 @default.
• W2979610535 cites W2743548462 @default.
• W2979610535 cites W2760479930 @default.
• W2979610535 cites W2782902833 @default.
• W2979610535 cites W2804059699 @default.
• W2979610535 cites W2891392885 @default.
• W2979610535 cites W34641758 @default.
• W2979610535 doi "https://doi.org/10.1016/j.bbi.2019.10.010" @default.
• W2979610535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31614176" @default.
• W2979610535 hasPublicationYear "2020" @default.
• W2979610535 type Work @default.
• W2979610535 sameAs 2979610535 @default.
• W2979610535 citedByCount "10" @default.
• W2979610535 countsByYear W29796105352020 @default.
• W2979610535 countsByYear W29796105352021 @default.
• W2979610535 countsByYear W29796105352022 @default.
• W2979610535 countsByYear W29796105352023 @default.
• W2979610535 crossrefType "journal-article" @default.
• W2979610535 hasAuthorship W2979610535A5005434770 @default.
• W2979610535 hasAuthorship W2979610535A5012250982 @default.
• W2979610535 hasAuthorship W2979610535A5023720185 @default.
• W2979610535 hasAuthorship W2979610535A5032613018 @default.
• W2979610535 hasAuthorship W2979610535A5035411450 @default.
• W2979610535 hasAuthorship W2979610535A5038435667 @default.
• W2979610535 hasAuthorship W2979610535A5051815938 @default.
• W2979610535 hasAuthorship W2979610535A5053894247 @default.
• W2979610535 hasAuthorship W2979610535A5064374185 @default.

• next