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- W2979617533 abstract "Extended travel in deep space poses potential hazards to the reproductive function of female and male astronauts, including exposure to cosmic radiation, microgravity, increased gravity (hypergravity), psychological stress, physical stress and circadian rhythm disruptions. This Review focuses on the effects of microgravity, hypergravity and cosmic radiation. Cosmic radiation contains protons, helium nuclei and high charge and energy (HZE) particles. Studies performed on Earth in which rodents were exposed to experimentally generated HZE particles have demonstrated a high sensitivity of ovarian follicles and spermatogenic cells to HZE particles. Exposure to microgravity during space flight and to simulated microgravity on Earth disrupts spermatogenesis and testicular testosterone synthesis in rodents, whereas the male reproductive system seems to adapt to exposure to moderate hypergravity. A few studies have investigated the effects of microgravity on female reproduction, with findings of disrupted oestrous cycling and in vitro follicle development being cause for concern. Many remaining data gaps need to be addressed, including the effects of microgravity, hypergravity and space radiation on the male and female reproductive tracts, hypothalamic–pituitary regulation of reproduction and prenatal development of the reproductive system as well as the combined effects of the multiple reproductive hazards encountered in space. This Review discusses the effects of space flight in low Earth orbit on reproductive end points in humans and experimental animals. The effects of simulated microgravity, hypergravity and experimentally generated space radiation on reproductive end points are also outlined." @default.
- W2979617533 created "2019-10-18" @default.
- W2979617533 creator A5014876537 @default.
- W2979617533 creator A5039209354 @default.
- W2979617533 date "2019-10-14" @default.
- W2979617533 modified "2023-10-06" @default.
- W2979617533 title "Reproductive hazards of space travel in women and men" @default.
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- W2979617533 doi "https://doi.org/10.1038/s41574-019-0267-6" @default.
- W2979617533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7371565" @default.
- W2979617533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31611649" @default.