FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979632008> ?p ?o ?g. }

• W2979632008 endingPage "151361" @default.
• W2979632008 startingPage "151361" @default.
• W2979632008 abstract "Urinary tract infections are one of the most common bacterial infections and a major public health problem. The predominant causative agents are uropathogenic Escherichia coli. These strains differ from commensal E. coli by the presence of additional horizontally acquired chromosomal material, so-called pathogenicity islands, which encode traits that promote efficient bacterial colonization of the urinary tract. Uropathogenic model strain E. coli 536 possesses six archetypal pathogenicity islands. Bacteriophage-like integrases encoded by each pathogenicity island contribute to island instability. To learn more about the stability of these six islands and factors controlling their stability we constructed two chromosomal reporter systems for the measurement of island loss, as well as for the measurement of the promoter activity of the six island-associated integrase genes at the population level. We used these reporter gene modules to analyze the role of SOS response in island instability. Tests with subinhibitory concentrations of different antibiotics, including many drugs commonly used for the treatment of urinary tract infection, indicated that only SOS response-inducing antibiotics led to an increased loss of islands which was always associated with an increase in the bacterial subpopulations showing high integrase promoter activity. This suggests that island excision correlates with the expression of the cognate integrase. Our reporter modules are valuable tools to investigate the impact of various growth conditions on genome plasticity. Furthermore, a better understanding of the conditions, which affect bacterial integrase expression may open ways to specifically manipulate the genome content of bacterial pathogens by increasing pathogenicity island deletion rates in infecting or colonizing bacteria, thus leading to the attenuation of bacterial pathogens." @default.
• W2979632008 created "2019-10-18" @default.
• W2979632008 creator A5015273008 @default.
• W2979632008 creator A5044244145 @default.
• W2979632008 creator A5073462462 @default.
• W2979632008 creator A5079061786 @default.
• W2979632008 date "2020-01-01" @default.
• W2979632008 modified "2023-09-27" @default.
• W2979632008 title "Sub-Inhibitory concentrations of SOS-Response inducing antibiotics stimulate integrase expression and excision of pathogenicity islands in uropathogenic Escherichia coli strain 536" @default.
• W2979632008 cites W1518048238 @default.
• W2979632008 cites W1529686752 @default.
• W2979632008 cites W1554248624 @default.
• W2979632008 cites W1617059328 @default.
• W2979632008 cites W1763885810 @default.
• W2979632008 cites W1857154095 @default.
• W2979632008 cites W1898328875 @default.
• W2979632008 cites W1969117927 @default.
• W2979632008 cites W1970480018 @default.
• W2979632008 cites W1976765185 @default.
• W2979632008 cites W1984864612 @default.
• W2979632008 cites W2009690857 @default.
• W2979632008 cites W2013637885 @default.
• W2979632008 cites W2031240692 @default.
• W2979632008 cites W2047606370 @default.
• W2979632008 cites W2050227017 @default.
• W2979632008 cites W2050896642 @default.
• W2979632008 cites W2054941036 @default.
• W2979632008 cites W2055825464 @default.
• W2979632008 cites W2064730121 @default.
• W2979632008 cites W2074879055 @default.
• W2979632008 cites W2075220585 @default.
• W2979632008 cites W2080021303 @default.
• W2979632008 cites W2081784844 @default.
• W2979632008 cites W2084413504 @default.
• W2979632008 cites W2084759112 @default.
• W2979632008 cites W2090751630 @default.
• W2979632008 cites W2093263361 @default.
• W2979632008 cites W2094448747 @default.
• W2979632008 cites W2094615886 @default.
• W2979632008 cites W2096642494 @default.
• W2979632008 cites W2096682277 @default.
• W2979632008 cites W2100303812 @default.
• W2979632008 cites W2101182625 @default.
• W2979632008 cites W2113565511 @default.
• W2979632008 cites W2116137883 @default.
• W2979632008 cites W2129742068 @default.
• W2979632008 cites W2130408429 @default.
• W2979632008 cites W2132682438 @default.
• W2979632008 cites W2134536451 @default.
• W2979632008 cites W2143426522 @default.
• W2979632008 cites W2146777285 @default.
• W2979632008 cites W2151183612 @default.
• W2979632008 cites W2151555844 @default.
• W2979632008 cites W2158921730 @default.
• W2979632008 cites W2163186898 @default.
• W2979632008 cites W2169036128 @default.
• W2979632008 cites W2209604872 @default.
• W2979632008 cites W2255408690 @default.
• W2979632008 cites W2402852007 @default.
• W2979632008 cites W2416418368 @default.
• W2979632008 cites W2514294413 @default.
• W2979632008 cites W26774890 @default.
• W2979632008 cites W2736694805 @default.
• W2979632008 cites W2790959541 @default.
• W2979632008 cites W2801432714 @default.
• W2979632008 cites W2942188629 @default.
• W2979632008 doi "https://doi.org/10.1016/j.ijmm.2019.151361" @default.
• W2979632008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31640923" @default.
• W2979632008 hasPublicationYear "2020" @default.
• W2979632008 type Work @default.
• W2979632008 sameAs 2979632008 @default.
• W2979632008 citedByCount "13" @default.
• W2979632008 countsByYear W29796320082020 @default.
• W2979632008 countsByYear W29796320082021 @default.
• W2979632008 countsByYear W29796320082022 @default.
• W2979632008 countsByYear W29796320082023 @default.
• W2979632008 crossrefType "journal-article" @default.
• W2979632008 hasAuthorship W2979632008A5015273008 @default.
• W2979632008 hasAuthorship W2979632008A5044244145 @default.
• W2979632008 hasAuthorship W2979632008A5073462462 @default.
• W2979632008 hasAuthorship W2979632008A5079061786 @default.
• W2979632008 hasBestOaLocation W29796320081 @default.
• W2979632008 hasConcept C104317684 @default.
• W2979632008 hasConcept C141231307 @default.
• W2979632008 hasConcept C14430832 @default.
• W2979632008 hasConcept C22744801 @default.
• W2979632008 hasConcept C2780258820 @default.
• W2979632008 hasConcept C2780852648 @default.
• W2979632008 hasConcept C2909909245 @default.
• W2979632008 hasConcept C3742359 @default.
• W2979632008 hasConcept C54355233 @default.
• W2979632008 hasConcept C547475151 @default.
• W2979632008 hasConcept C62130838 @default.
• W2979632008 hasConcept C86803240 @default.
• W2979632008 hasConcept C89423630 @default.
• W2979632008 hasConceptScore W2979632008C104317684 @default.
• W2979632008 hasConceptScore W2979632008C141231307 @default.
• W2979632008 hasConceptScore W2979632008C14430832 @default.

• next