FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979640794> ?p ?o ?g. }

• W2979640794 abstract "Glioblastoma multiforme (GBM) is a kind of malignant brain tumor prevalent in adults, with the characteristics well adapted to poorly immunogenic and hypoxic conditions. Effective treatment of GBM is impeded due to the high proliferation, migration and invasion of GBM cells. GBM cells migrate by degrading the extracellular matrix, so it is difficult to have GBM cells eradicated completely by surgery. This study aims to confirm that miR-431-5p could influence the proliferation, invasion and migration of human glioblastoma multiforme cells by targeting EPB41L1 (erythrocyte membrane protein band 4.1).The expression levels of miR-431-5p and EPB41L1 were detected in GBM cells and tissues using qRT-PCR. Dual luciferase reporter gene assay and western blot were applied to confirm the targeting relationship between miR-431-5p and EPB41L1. GBM cell line U87 was used in MTT, flow cytometry, Transwell, and wound healing assays to determine cell proliferation, migration and invasion.MiR-431-5p was overexpressed in GBM tissues while EPB41L1 was under-expressed. The results of dual luciferase reporter gene assay and western blot demonstrated that miR-431-5p could target EPB41L1 and suppress its expression. Down-regulating the expression of miR-431-5p or up-regulating the expression of EPB41L1 could inhibit the proliferation, invasion and migration but promote the apoptosis of GBM cells.MiR-431-5p facilitated the progression of GBM by inhibiting EPB41L1 expression." @default.
• W2979640794 created "2019-10-18" @default.
• W2979640794 creator A5003759585 @default.
• W2979640794 creator A5016314993 @default.
• W2979640794 creator A5017578987 @default.
• W2979640794 creator A5030961741 @default.
• W2979640794 date "2019-01-01" @default.
• W2979640794 modified "2023-10-01" @default.
• W2979640794 title "Mechanism of microRNA-431-5p-EPB41L1 interaction in glioblastoma multiforme cells" @default.
• W2979640794 cites W1213846354 @default.
• W2979640794 cites W1705704138 @default.
• W2979640794 cites W1858260015 @default.
• W2979640794 cites W1903653456 @default.
• W2979640794 cites W1979468053 @default.
• W2979640794 cites W1993092248 @default.
• W2979640794 cites W2005003076 @default.
• W2979640794 cites W2010237285 @default.
• W2979640794 cites W2019009111 @default.
• W2979640794 cites W2036044314 @default.
• W2979640794 cites W2041723928 @default.
• W2979640794 cites W2047903790 @default.
• W2979640794 cites W2047948621 @default.
• W2979640794 cites W2059537862 @default.
• W2979640794 cites W2072003338 @default.
• W2979640794 cites W2079137508 @default.
• W2979640794 cites W2089841176 @default.
• W2979640794 cites W2096287682 @default.
• W2979640794 cites W2098107333 @default.
• W2979640794 cites W2104381279 @default.
• W2979640794 cites W2148460663 @default.
• W2979640794 cites W2151939392 @default.
• W2979640794 cites W2154038132 @default.
• W2979640794 cites W2158681922 @default.
• W2979640794 cites W2164194749 @default.
• W2979640794 cites W2165871546 @default.
• W2979640794 cites W2173969854 @default.
• W2979640794 cites W2190790361 @default.
• W2979640794 cites W2240638205 @default.
• W2979640794 cites W2265820530 @default.
• W2979640794 cites W2268641015 @default.
• W2979640794 cites W2276985297 @default.
• W2979640794 cites W2278864388 @default.
• W2979640794 cites W2288478716 @default.
• W2979640794 cites W2293295315 @default.
• W2979640794 cites W2307662723 @default.
• W2979640794 cites W2326264847 @default.
• W2979640794 cites W2396371192 @default.
• W2979640794 cites W2400821311 @default.
• W2979640794 cites W2461279556 @default.
• W2979640794 cites W2462802420 @default.
• W2979640794 cites W2466111283 @default.
• W2979640794 cites W2470910400 @default.
• W2979640794 cites W2551452367 @default.
• W2979640794 cites W2552916641 @default.
• W2979640794 cites W2555854562 @default.
• W2979640794 cites W2566237707 @default.
• W2979640794 cites W2581781017 @default.
• W2979640794 cites W2615997087 @default.
• W2979640794 cites W2901528543 @default.
• W2979640794 doi "https://doi.org/10.5114/aoms.2019.88274" @default.
• W2979640794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6855151" @default.
• W2979640794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31749885" @default.
• W2979640794 hasPublicationYear "2019" @default.
• W2979640794 type Work @default.
• W2979640794 sameAs 2979640794 @default.
• W2979640794 citedByCount "4" @default.
• W2979640794 countsByYear W29796407942020 @default.
• W2979640794 countsByYear W29796407942021 @default.
• W2979640794 countsByYear W29796407942023 @default.
• W2979640794 crossrefType "journal-article" @default.
• W2979640794 hasAuthorship W2979640794A5003759585 @default.
• W2979640794 hasAuthorship W2979640794A5016314993 @default.
• W2979640794 hasAuthorship W2979640794A5017578987 @default.
• W2979640794 hasAuthorship W2979640794A5030961741 @default.
• W2979640794 hasBestOaLocation W29796407941 @default.
• W2979640794 hasConcept C104317684 @default.
• W2979640794 hasConcept C11957725 @default.
• W2979640794 hasConcept C128473837 @default.
• W2979640794 hasConcept C137738243 @default.
• W2979640794 hasConcept C145059251 @default.
• W2979640794 hasConcept C150194340 @default.
• W2979640794 hasConcept C161733203 @default.
• W2979640794 hasConcept C189165786 @default.
• W2979640794 hasConcept C190283241 @default.
• W2979640794 hasConcept C203014093 @default.
• W2979640794 hasConcept C2776194525 @default.
• W2979640794 hasConcept C2776415932 @default.
• W2979640794 hasConcept C2780783641 @default.
• W2979640794 hasConcept C502942594 @default.
• W2979640794 hasConcept C54355233 @default.
• W2979640794 hasConcept C553184892 @default.
• W2979640794 hasConcept C55493867 @default.
• W2979640794 hasConcept C62112901 @default.
• W2979640794 hasConcept C71924100 @default.
• W2979640794 hasConcept C81885089 @default.
• W2979640794 hasConcept C86803240 @default.
• W2979640794 hasConcept C95444343 @default.
• W2979640794 hasConceptScore W2979640794C104317684 @default.
• W2979640794 hasConceptScore W2979640794C11957725 @default.
• W2979640794 hasConceptScore W2979640794C128473837 @default.

• next