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• W2979647598 abstract "Objective: we present a multiscale agent-based model of Ductal Carcinoma in Situ (DCIS) in order to gain a detailed understanding of the cell-scale population dynamics, phenotypic distributions, and the associated interplay of important molecular signaling pathways that are involved in DCIS ductal invasion into the duct cavity (a process we refer to as duct advance rate here). Methods: DCIS is modeled mathematically through a hybridized discrete cell-scale model and a continuum molecular scale model, which are explicitly linked through a bidirectional feedback mechanism. Results: we find that duct advance rates occur in two distinct phases, characterized by an early exponential population expansion, followed by a long-term steady linear phase of population expansion, a result that is consistent with other modeling work. We further found that the rates were influenced most strongly by endocrine and paracrine signaling intensity, as well as by the effects of cell density induced quiescence within the DCIS population. Conclusion: our model analysis identified a complex interplay between phenotypic diversity that may provide a tumor adaptation mechanism to overcome proliferation limiting conditions, allowing for dynamic shifts in phenotypic populations in response to variation in molecular signaling intensity. Further, sensitivity analysis determined DCIS axial advance rates and calcification rates were most sensitive to cell cycle time variation. Significance: this model may serve as a useful tool to study the cell-scale dynamics involved in DCIS initiation and intraductal invasion, and may provide insights into promising areas of future experimental research." @default.
• W2979647598 created "2019-10-18" @default.
• W2979647598 creator A5004315502 @default.
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• W2979647598 date "2020-05-01" @default.
• W2979647598 modified "2023-10-14" @default.
• W2979647598 title "A Multiscale Agent-Based Model of Ductal Carcinoma<i>In Situ</i>" @default.
• W2979647598 cites W1509631798 @default.
• W2979647598 cites W1565036272 @default.
• W2979647598 cites W1963558489 @default.
• W2979647598 cites W1969375579 @default.
• W2979647598 cites W1969737253 @default.
• W2979647598 cites W1973148098 @default.
• W2979647598 cites W1982501243 @default.
• W2979647598 cites W1991471911 @default.
• W2979647598 cites W1993805713 @default.
• W2979647598 cites W1995661435 @default.
• W2979647598 cites W2003670869 @default.
• W2979647598 cites W2011911766 @default.
• W2979647598 cites W2013507620 @default.
• W2979647598 cites W2013945372 @default.
• W2979647598 cites W2014769181 @default.
• W2979647598 cites W2015801956 @default.
• W2979647598 cites W2016929953 @default.
• W2979647598 cites W2019681680 @default.
• W2979647598 cites W2020842741 @default.
• W2979647598 cites W2020925016 @default.
• W2979647598 cites W2022916138 @default.
• W2979647598 cites W2024716288 @default.
• W2979647598 cites W2030683290 @default.
• W2979647598 cites W2034631682 @default.
• W2979647598 cites W2038685807 @default.
• W2979647598 cites W2041785903 @default.
• W2979647598 cites W2043436133 @default.
• W2979647598 cites W2051752778 @default.
• W2979647598 cites W2054297703 @default.
• W2979647598 cites W2055384999 @default.
• W2979647598 cites W2064002346 @default.
• W2979647598 cites W2066288526 @default.
• W2979647598 cites W2068716083 @default.
• W2979647598 cites W2075604674 @default.
• W2979647598 cites W2082654353 @default.
• W2979647598 cites W2083610791 @default.
• W2979647598 cites W2089361444 @default.
• W2979647598 cites W2090516705 @default.
• W2979647598 cites W2090722238 @default.
• W2979647598 cites W2097025096 @default.
• W2979647598 cites W2105095873 @default.
• W2979647598 cites W2109278571 @default.
• W2979647598 cites W2115168672 @default.
• W2979647598 cites W2122995470 @default.
• W2979647598 cites W2124357987 @default.
• W2979647598 cites W2124487399 @default.
• W2979647598 cites W2125857415 @default.
• W2979647598 cites W2127225632 @default.
• W2979647598 cites W2129627597 @default.
• W2979647598 cites W2136269628 @default.
• W2979647598 cites W2141704910 @default.
• W2979647598 cites W2142171814 @default.
• W2979647598 cites W2151138778 @default.
• W2979647598 cites W2151948621 @default.
• W2979647598 cites W2153521785 @default.
• W2979647598 cites W2156678998 @default.
• W2979647598 cites W2158734140 @default.
• W2979647598 cites W2158832908 @default.
• W2979647598 cites W2160720198 @default.
• W2979647598 cites W2169491501 @default.
• W2979647598 cites W2169961781 @default.
• W2979647598 cites W2183086862 @default.
• W2979647598 cites W2320762778 @default.
• W2979647598 cites W2343365710 @default.
• W2979647598 cites W2410611073 @default.
• W2979647598 cites W2494434795 @default.
• W2979647598 cites W2574909578 @default.
• W2979647598 cites W2734569735 @default.
• W2979647598 cites W2754698287 @default.
• W2979647598 cites W2765730936 @default.
• W2979647598 cites W2784563802 @default.
• W2979647598 cites W2792705224 @default.
• W2979647598 cites W2807114123 @default.
• W2979647598 cites W2912919165 @default.
• W2979647598 cites W2928663587 @default.
• W2979647598 cites W2949797623 @default.
• W2979647598 cites W4243727397 @default.
• W2979647598 cites W4255002869 @default.
• W2979647598 cites W4255756682 @default.
• W2979647598 cites W4360754826 @default.
• W2979647598 cites W51269470 @default.
• W2979647598 cites W973310309 @default.
• W2979647598 doi "https://doi.org/10.1109/tbme.2019.2938485" @default.
• W2979647598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8445608" @default.
• W2979647598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31603768" @default.

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