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- W2979651256 abstract "Considering the pathogenesis of prolactin-secreting pituitary adenomas, one should not regard this problem as a purely academic one, considering that mutations in genes and disruptions in the pituitary cell genome are a rather rare process. On the contrary, almost every second living person is a carrier of a violation in the pituitary cell genome, leading to the formation of an adenoma throughout life. Thus, over half a century, various authors emphasized that among non-selective autopsy material, the prevalence (up to 27-30% or more) of pituitary adenomas, which have no clinical manifestation, is unusually high [24]. The materials of analytical studies of recent years also show a lower (11-23%), but still quite significant level of detection of pituitary adenomas in the section [18, 59]. Assessment of intravital prevalence of asymptomatic pituitary adenomas performed in 100 volunteers (70 women and 30 men) using magnetic resonance imaging (MRI) with contrasting gadolinium showed that among healthy volunteers of both sexes they occur in approximately 10% of cases (7 women and 3 men), varying from 3 to 6 mm in diameter [42]. A similar study performed among healthy women of reproductive age using high-resolution computed tomography (CT) scans (overlapping sections 1.5 mm thick) showed the same frequency of occurrence of such pituitary anomalies [85]." @default.
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- W2979651256 date "2000-04-15" @default.
- W2979651256 modified "2023-09-25" @default.
- W2979651256 title "Modern ideas about the genesis of prolactin-secreting pituitary adenomas" @default.
- W2979651256 doi "https://doi.org/10.14341/probl11840" @default.
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