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- W2979656768 abstract "Abstract The CO 2 receptor in mosquitoes is broadly tuned to detect many diverse odorants. The receptor consists of three 7-TM subunits (Gr1, Gr2, and Gr3) in mosquitoes but only two subunits in Drosophila : Gr21a (Gr1 ortholog) and Gr63a (Gr3 ortholog). We demonstrate that Gr21a is required for CO 2 responses in Drosophila as has been shown for Gr63a . Next, we generate a Drosophila double mutant for Gr21a and Gr63a , and in this background we functionally express combinations of Aedes Gr1, 2 , and 3 genes in the “CO 2 empty neuron.” Only two subunits, Gr2 and Gr3, suffice for response to CO 2 . Addition of Gr1 increases sensitivity to CO 2 while it decreases the response to pyridine. The inhibitory effect of the antagonist isobutyric acid is observed upon addition of Gr1. Gr1 therefore increases the diversity of ligands of the receptor, and also modulates the response of the receptor complex." @default.
- W2979656768 created "2019-10-18" @default.
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- W2979656768 date "2019-10-13" @default.
- W2979656768 modified "2023-09-25" @default.
- W2979656768 title "Contributions of the conserved insect carbon dioxide receptor subunits to odor detection" @default.
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- W2979656768 doi "https://doi.org/10.1101/803270" @default.
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