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- W2979668769 abstract "Abstract Anti-arrhythmic effects of nadolol on experimental arrhythmias produced by three methods were investigated in anesthetized dogs (30 mg/kg i.v. of sodium pentobarbital) and were compared with those of propranolol and alprenolol. I.v. infusion of ouabain (1 μg/kg/min)caused the ventricular arrhythmias (first extrasystole, 36.4±3.4 min; ventricular tachycardia, 51.9+4.9 ; ventricular fibrillation,74.2+4.6). Halothane-adrenaline arrhythmias showed the minor VA including sinus beats (initially bigeminy followed by multifocal VA). The acute coronary ligation caused the electrical alternans (STT segment) followed by VA. Low dose of nadolol (10 μg/kg) showed a marked protective effect on the arrhythmias produced by adrenaline and coronary ligation, while ouabain-arrhythmias were not modified with increasing doses. On the other hand, 10 μg/kg of propranolol and alprenolol showed marked protective effects on the ouabain-arrhythmias, while the same effects on those by adrenaline and coronary ligation were induced with high doses (0.1 - 0.2 mg/kg)." @default.
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- W2979668769 date "1983-01-01" @default.
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- W2979668769 title "Anti-arrhythmic effects of nadolol on experimental arrhythmias in dogs." @default.
- W2979668769 doi "https://doi.org/10.1016/s0021-5198(19)64963-2" @default.
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