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- W2979677739 endingPage "298" @default.
- W2979677739 startingPage "290" @default.
- W2979677739 abstract "Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior.In this research, we determined the promoter methylation status of four tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For methylation, we used the methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls.Our data showed that the promoter methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0.05. The most significant differences were observed in RASSF1; 77.2% of hyper-methylated PTC patients versus 15.6% hyper-methylated goiter samples (P<0.001).RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation." @default.
- W2979677739 created "2019-10-18" @default.
- W2979677739 creator A5007232361 @default.
- W2979677739 creator A5014479724 @default.
- W2979677739 creator A5014688092 @default.
- W2979677739 creator A5028403457 @default.
- W2979677739 creator A5036199850 @default.
- W2979677739 creator A5083950596 @default.
- W2979677739 creator A5087677964 @default.
- W2979677739 creator A5088835666 @default.
- W2979677739 date "2019-09-22" @default.
- W2979677739 modified "2023-10-15" @default.
- W2979677739 title "Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma" @default.
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