FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979679121> ?p ?o ?g. }

• W2979679121 endingPage "229" @default.
• W2979679121 startingPage "216" @default.
• W2979679121 abstract "Summary Galectin-3 is the best-characterized member of galectins, an evolutionary conserved family of galactoside-binding proteins that play central roles in infection and immunity, regulating inflammation, cell migration and cell apoptosis. Differentially expressed by cells and tissues with immune privilege, they bind not only to host ligands, but also to glycans expressed by pathogens. In this regard, we have previously shown that human galectin-3 recognizes several genetic lineages of the protozoan parasite Trypanosoma cruzi, the causal agent of Chagas’ disease or American trypanosomiasis. Herein we describe a molecular mechanism developed by T. cruzi to proteolytically process galectin-3 that generates a truncated form of the protein lacking its N-terminal domain – required for protein oligomerization – but still conserves a functional carbohydrate recognition domain (CRD). Such processing relies on specific T. cruzi proteases, including Zn-metalloproteases and collagenases, and ultimately conveys profound changes in galectin-3-dependent effects, as chemical inhibition of parasite proteases allows galectin-3 to induce parasite death in vitro. Thus, T. cruzi might have established distinct mechanisms to counteract galectin-3-mediated immunity and microbicide properties. Interestingly, non-pathogenic T. rangeli lacked the ability to cleave galectin-3, suggesting that during evolution two genetically similar organisms have developed different molecular mechanisms that, in the case of T. cruzi, favoured its pathogenicity, highlighting the importance of T. cruzi proteases to avoid immune mechanisms triggered by galectin-3 upon infection. This study provides the first evidence of a novel strategy developed by T. cruzi to abrogate signalling mechanisms associated with galectin-3-dependent innate immunity." @default.
• W2979679121 created "2019-10-18" @default.
• W2979679121 creator A5063080095 @default.
• W2979679121 creator A5065018206 @default.
• W2979679121 creator A5071897140 @default.
• W2979679121 creator A5076272487 @default.
• W2979679121 creator A5091177745 @default.
• W2979679121 date "2019-10-27" @default.
• W2979679121 modified "2023-10-14" @default.
• W2979679121 title "<i>Trypanosoma cruzi</i> cleaves galectin-3 N-terminal domain to suppress its innate microbicidal activity" @default.
• W2979679121 cites W148772713 @default.
• W2979679121 cites W1576409652 @default.
• W2979679121 cites W1763310158 @default.
• W2979679121 cites W1836918009 @default.
• W2979679121 cites W1886517296 @default.
• W2979679121 cites W1924186013 @default.
• W2979679121 cites W1979487024 @default.
• W2979679121 cites W1979628965 @default.
• W2979679121 cites W1985965035 @default.
• W2979679121 cites W1991771659 @default.
• W2979679121 cites W1992006091 @default.
• W2979679121 cites W1996600059 @default.
• W2979679121 cites W2001349696 @default.
• W2979679121 cites W2002458386 @default.
• W2979679121 cites W2004765779 @default.
• W2979679121 cites W2006714159 @default.
• W2979679121 cites W2010944762 @default.
• W2979679121 cites W2013466449 @default.
• W2979679121 cites W2024013484 @default.
• W2979679121 cites W2031798405 @default.
• W2979679121 cites W2034325006 @default.
• W2979679121 cites W2036321259 @default.
• W2979679121 cites W2039939971 @default.
• W2979679121 cites W2045697716 @default.
• W2979679121 cites W2052578371 @default.
• W2979679121 cites W2054590741 @default.
• W2979679121 cites W2058049578 @default.
• W2979679121 cites W2063636552 @default.
• W2979679121 cites W2066058896 @default.
• W2979679121 cites W2067080331 @default.
• W2979679121 cites W2079153892 @default.
• W2979679121 cites W2090205082 @default.
• W2979679121 cites W2090910318 @default.
• W2979679121 cites W2102867745 @default.
• W2979679121 cites W2110451407 @default.
• W2979679121 cites W2113928427 @default.
• W2979679121 cites W2126266031 @default.
• W2979679121 cites W2126578659 @default.
• W2979679121 cites W2127121599 @default.
• W2979679121 cites W2132472673 @default.
• W2979679121 cites W2143328756 @default.
• W2979679121 cites W2146222746 @default.
• W2979679121 cites W2151551515 @default.
• W2979679121 cites W2152853164 @default.
• W2979679121 cites W2157903759 @default.
• W2979679121 cites W2164471400 @default.
• W2979679121 cites W2170252526 @default.
• W2979679121 cites W2170747616 @default.
• W2979679121 cites W2235696548 @default.
• W2979679121 cites W2471339379 @default.
• W2979679121 cites W2490047585 @default.
• W2979679121 cites W2610090469 @default.
• W2979679121 cites W2772141281 @default.
• W2979679121 cites W2894171124 @default.
• W2979679121 cites W4210980497 @default.
• W2979679121 doi "https://doi.org/10.1111/cei.13379" @default.
• W2979679121 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6954680" @default.
• W2979679121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31593356" @default.
• W2979679121 hasPublicationYear "2019" @default.
• W2979679121 type Work @default.
• W2979679121 sameAs 2979679121 @default.
• W2979679121 citedByCount "3" @default.
• W2979679121 countsByYear W29796791212021 @default.
• W2979679121 countsByYear W29796791212022 @default.
• W2979679121 crossrefType "journal-article" @default.
• W2979679121 hasAuthorship W2979679121A5063080095 @default.
• W2979679121 hasAuthorship W2979679121A5065018206 @default.
• W2979679121 hasAuthorship W2979679121A5071897140 @default.
• W2979679121 hasAuthorship W2979679121A5076272487 @default.
• W2979679121 hasAuthorship W2979679121A5091177745 @default.
• W2979679121 hasBestOaLocation W29796791211 @default.
• W2979679121 hasConcept C112418997 @default.
• W2979679121 hasConcept C136449434 @default.
• W2979679121 hasConcept C136764020 @default.
• W2979679121 hasConcept C156293190 @default.
• W2979679121 hasConcept C17172800 @default.
• W2979679121 hasConcept C181199279 @default.
• W2979679121 hasConcept C182220744 @default.
• W2979679121 hasConcept C203014093 @default.
• W2979679121 hasConcept C2776914184 @default.
• W2979679121 hasConcept C2777209026 @default.
• W2979679121 hasConcept C2777625466 @default.
• W2979679121 hasConcept C41008148 @default.
• W2979679121 hasConcept C55493867 @default.
• W2979679121 hasConcept C71928629 @default.
• W2979679121 hasConcept C86803240 @default.
• W2979679121 hasConcept C8891405 @default.
• W2979679121 hasConcept C89423630 @default.

• next