FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2979681954> ?p ?o ?g. }

• W2979681954 abstract "The presence of an extremely stable latent reservoir of HIV-1 is the major obstacle to eradication, despite effective antiretroviral therapy (ART). Recent studies have shown that clonal expansion of latently infected cells without viral reactivation is an important phenomenon that maintains the long-term stability of the reservoir, yet its underlying mechanism remains unclear. Here we report that a subset of CD4+ T cells, characterized by CD161 expression on the surface, is highly permissive for HIV-1 infection. These cells possess a significantly higher survival and proliferative capacity than their CD161-negative counterparts. More importantly, we found that these cells harbor HIV-1 DNA and replication-competent latent viruses at a significantly higher frequency. By using massive single-genome proviral sequencing from ART-suppressed individuals, we confirm that CD161+ CD4+ T cells contain remarkably more identical proviral sequences, indicating clonal expansion of the viral genome in these cells. Taking the results together, our study identifies infected CD161+ CD4+ T cells to be a critical force driving the clonal expansion of the HIV-1 latent reservoir, providing a novel mechanism for the long-term stability of HIV-1 latency.IMPORTANCE The latent reservoir continues to be the major obstacle to curing HIV-1 infection. The clonal expansion of latently infected cells adds another layer maintaining the long-term stability of the reservoir, but its mechanism remains unclear. Here, we report that CD161+ CD4+ T cells serve as an important compartment of the HIV-1 latent reservoir and contain a significant amount of clonally expanded proviruses. In our study, we describe a feasible strategy that may reduce the size of the latent reservoir to a certain extent by counterbalancing the repopulation and dissemination of latently infected cells." @default.
• W2979681954 created "2019-10-18" @default.
• W2979681954 creator A5000192476 @default.
• W2979681954 creator A5002424418 @default.
• W2979681954 creator A5003297746 @default.
• W2979681954 creator A5004729914 @default.
• W2979681954 creator A5020176677 @default.
• W2979681954 creator A5045423164 @default.
• W2979681954 creator A5047495310 @default.
• W2979681954 creator A5050925013 @default.
• W2979681954 creator A5054844539 @default.
• W2979681954 creator A5065047387 @default.
• W2979681954 creator A5078464222 @default.
• W2979681954 creator A5084789982 @default.
• W2979681954 date "2019-10-29" @default.
• W2979681954 modified "2023-10-16" @default.
• W2979681954 title "CD161 ⁺ CD4 ⁺ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals" @default.
• W2979681954 cites W1484085688 @default.
• W2979681954 cites W1549187729 @default.
• W2979681954 cites W1749946895 @default.
• W2979681954 cites W1964077677 @default.
• W2979681954 cites W1975164490 @default.
• W2979681954 cites W1978860647 @default.
• W2979681954 cites W1979787704 @default.
• W2979681954 cites W1985447596 @default.
• W2979681954 cites W1995391551 @default.
• W2979681954 cites W2008483698 @default.
• W2979681954 cites W2010234200 @default.
• W2979681954 cites W2011770661 @default.
• W2979681954 cites W2036378796 @default.
• W2979681954 cites W2051269276 @default.
• W2979681954 cites W2052756867 @default.
• W2979681954 cites W2060829964 @default.
• W2979681954 cites W2064416623 @default.
• W2979681954 cites W2075106941 @default.
• W2979681954 cites W2090646713 @default.
• W2979681954 cites W2101516953 @default.
• W2979681954 cites W2103119361 @default.
• W2979681954 cites W2106051882 @default.
• W2979681954 cites W2112173990 @default.
• W2979681954 cites W2114538357 @default.
• W2979681954 cites W2116875138 @default.
• W2979681954 cites W2124114936 @default.
• W2979681954 cites W2139250164 @default.
• W2979681954 cites W2144549163 @default.
• W2979681954 cites W2147172932 @default.
• W2979681954 cites W2168951760 @default.
• W2979681954 cites W2168952458 @default.
• W2979681954 cites W2171196763 @default.
• W2979681954 cites W2205289348 @default.
• W2979681954 cites W2272185077 @default.
• W2979681954 cites W2275979138 @default.
• W2979681954 cites W2329393410 @default.
• W2979681954 cites W2462078368 @default.
• W2979681954 cites W2517479804 @default.
• W2979681954 cites W2551663169 @default.
• W2979681954 cites W2595002955 @default.
• W2979681954 cites W2598871150 @default.
• W2979681954 cites W2625399959 @default.
• W2979681954 cites W2751083076 @default.
• W2979681954 cites W2766409016 @default.
• W2979681954 cites W2766543637 @default.
• W2979681954 cites W2787916478 @default.
• W2979681954 cites W2794108759 @default.
• W2979681954 cites W2803250240 @default.
• W2979681954 cites W2803774634 @default.
• W2979681954 cites W2911228036 @default.
• W2979681954 cites W2914054854 @default.
• W2979681954 cites W3041619909 @default.
• W2979681954 doi "https://doi.org/10.1128/mbio.02121-19" @default.
• W2979681954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6786872" @default.
• W2979681954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31594817" @default.
• W2979681954 hasPublicationYear "2019" @default.
• W2979681954 type Work @default.
• W2979681954 sameAs 2979681954 @default.
• W2979681954 citedByCount "18" @default.
• W2979681954 countsByYear W29796819542020 @default.
• W2979681954 countsByYear W29796819542021 @default.
• W2979681954 countsByYear W29796819542022 @default.
• W2979681954 countsByYear W29796819542023 @default.
• W2979681954 crossrefType "journal-article" @default.
• W2979681954 hasAuthorship W2979681954A5000192476 @default.
• W2979681954 hasAuthorship W2979681954A5002424418 @default.
• W2979681954 hasAuthorship W2979681954A5003297746 @default.
• W2979681954 hasAuthorship W2979681954A5004729914 @default.
• W2979681954 hasAuthorship W2979681954A5020176677 @default.
• W2979681954 hasAuthorship W2979681954A5045423164 @default.
• W2979681954 hasAuthorship W2979681954A5047495310 @default.
• W2979681954 hasAuthorship W2979681954A5050925013 @default.
• W2979681954 hasAuthorship W2979681954A5054844539 @default.
• W2979681954 hasAuthorship W2979681954A5065047387 @default.
• W2979681954 hasAuthorship W2979681954A5078464222 @default.
• W2979681954 hasAuthorship W2979681954A5084789982 @default.
• W2979681954 hasBestOaLocation W29796819541 @default.
• W2979681954 hasConcept C140704245 @default.
• W2979681954 hasConcept C142462285 @default.
• W2979681954 hasConcept C159047783 @default.
• W2979681954 hasConcept C203014093 @default.
• W2979681954 hasConcept C2522874641 @default.
• W2979681954 hasConcept C2778852064 @default.

• next