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• W2979683083 abstract "Abstract An in‐depth understanding of circular RNAs (circRNAs) indicates that they are abundant in the eukaryotic transcriptome. Many circRNAs act as microRNA sponges; thus, they represent a new type of regulatory factor. However, the role of circRNA in colorectal cancer (CRC) remains largely unknown. Low circ_0021977 expression in patients with CRC is associated with higher tug‐lymph node metastasis (TNM) stage and poorer prognosis compared with patients with high circ_0021977 expression. Moreover, miR‐10b‐5p was shown to be a target of circ_0021977, and p21 and p53 are suggested to be putative target genes of miR‐10b‐5p. The results showed that the circ_0021977/miR‐10b‐5p/p21&p53 regulatory axis suppresses proliferation, migration, and invasion by CRC cells. This evidence reveals new relationships and brings new highlights to the treatment of CRC." @default.
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• W2979683083 date "2019-10-08" @default.
• W2979683083 modified "2023-10-13" @default.
• W2979683083 title "The circ_0021977/miR‐10b‐5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer" @default.
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• W2979683083 doi "https://doi.org/10.1002/jcp.29135" @default.
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