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• W2979706246 abstract "Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative procedure for several hematological malignancies. Haploidentical HSCT (haplo-HSCT) using high-dose post-transplantation cyclophosphamide (PTCy) makes transplantation possible for patients with no HLA-matched sibling donor. However, this treatment can cause complications, mainly infection, graft-versus-host disease (GVHD), and conditioning-related toxicity. In recent years, different biomarkers in the form of tissue-specific proteins have been investigated; these may help us to predict complications of allo-HSCT. In this study we explored two such biomarkers, suppression of tumorigenicity 2 (ST2) and regenerating islet-derived 3α (REG3α), in the largest series reported of T cell–replete haplo-HSCT with PTCy. Plasma samples drawn from 87 patients at days +15 and +30 were analyzed. ST2 and REG3α levels at day +15 were not associated with post-transplant complications. ST2 levels at day +30 were higher in patients with grade II-IV acute GVHD, mainly those who received reduced intensity conditioning (RIC; median 2503 vs. 1830 ng/ml; p=0.04). Of note, patients with higher plasma ST2 levels at day +30 also presented a higher incidence of non-relapse mortality (HR, 7.9; p=0.004) and lower two-year overall survival (25 vs. 44 months; p=0.02) than patients with lower levels. Patients with REG3α levels higher than 1989 pg/ml at day +30 presented a higher incidence of acute gastrointestinal GVHD in the whole cohort (HR, 8.37; p=0.003) and in the RIC cohort (HR 6.59; p=0.01). These data suggest that measurement of ST2 and REG3α might be useful for the prognosis and prediction of complications in patients undergoing Haplo-HSCT with PTCy." @default.
• W2979706246 created "2019-10-18" @default.
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• W2979706246 date "2019-10-09" @default.
• W2979706246 modified "2023-10-18" @default.
• W2979706246 title "ST2 and REG3α as Predictive Biomarkers After Haploidentical Stem Cell Transplantation Using Post-transplantation High-Dose Cyclophosphamide" @default.
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• W2979706246 doi "https://doi.org/10.3389/fimmu.2019.02338" @default.
• W2979706246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6794466" @default.
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